Skip to main content
OpenTrials
Completed

NCT Number: NCT02186990

Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

The purpose of this study is to evaluate the effect of propofol, etomidate and propofol-etomidate combination on hemodynamic responses during laryngoscopy and tracheal intubation and assess the adverse effect related to this drugs.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Induction of Anaesthesia

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital

Altinordu, Ordu, 52100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • between 18 - 65 age
  • ASA I - II status
  • elective surgery

Exclusion criteria

  • emergency surgery
  • pregnancy
  • alcohol and drug abuse
  • HT and cardiovascular disease
  • BMI > 25 kg/m2
  • hypersensitivity against study drug
  • sedative drug use in last month
  • difficult intubation

Treatment and study plan

Propofol

Drug

2,5 mg/kg

Etomidate

Drug

0,3 mg/kg

etomidate-propofol

Drug

0,15 mg/kg etomidate + 1,25 mg/kg propofol

Primary outcomes

  1. haemodynamic values

    Time frame: in ten minutes after intubation

    e.g., heart rate, blood pressure (mean arterial pressure)

Secondary outcomes

  1. adverse effect of study drugs

    Time frame: within in 30 minutes drug administration

    e.g. myoclonus, injection pain, allergy, skin rash

Sponsors and collaborators

Lead sponsor

Ordu University

Other

Registry information

Important dates

Study start
2014
Primary completion
2014
First posted
Jul 10, 2014
Registry last updated
Aug 13, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.