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OpenTrials
Completed

NCT Number: NCT06611267

Experiences of Pain in Healthy Adults

The experiment aims to investigate the experience of pain in healthy adults and includes a total of 60 participants. Pain is a subjective experience that has a complicated neurological and psychological basis. Around 20% of the Danish population suffers from persistent pain, which has both personal and societal consequences. Personal consequences include, among others, reduced quality of life, loss of social life and risk of anxiety and depression. However, more knowledge is needed about which mechanisms are involved in the experience of pain, so that the treatment of patients with pain can be improved.

In the experiment, healthy participants will be inflicted with a tolerable pain on their forearm using a thermode. The application of heat causes pain for a short, limited period, but it is tolerable and without risks. During the experiment, the participants will be exposed to heat several times, with and without a cream on their forearm. It is a cream that has previously proved to have pain-relieving effects on participants in similar experiments. Participants will be asked about how they experience the intensity of the pain on a scale of 1-10 (0 = no pain and 10 = worst imaginable pain), and what they expect the pain intensity will be, also on a 1-10 scale. The participants are allowed to pause or stop the experiment anytime.

The experiment contributes to insights into pain and the mechanisms involved. This knowledge can in the future contribute with knowledge to improve the treatment of patients with pain. For the individual participant, the trial will contribute with knowledge about how they experience and assess pain themselves.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Aarhus University

Aarhus C, 8000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal health, i.e. no known acute or chronic illness
  • Fluid in Danish

Exclusion criteria

  • Chronic pain condition
  • Other medical or psychiatric disorder
  • Use of antidepressants
  • Daily use of painkillers
  • Use of pain medication 24 hours prior to testing
  • Drug abuse
  • Pregnancy
  • Studying or with completed education in psychology or journalism

Treatment and study plan

Pain without cream on

Other

Participants will be inflicted with pain without cream on.

Pain with cream on

Other

Patients are inflicted with pain after getting a cream on, which has previously had pain-relieving effects

Primary outcomes

  1. Experienced pain measured on a Visual Analogue Scale (VAS) from 0-10 (from no pain to worst imaginable pain) without cream compared to experienced pain measured on a Visual Analogue Scale (VAS) from 0-10 (from no pain to worst imaginable pain) with cream

    Time frame: From beginning to end of experiment, approx. 45 minutes

Secondary outcomes

  1. The effect of assessing expected pain intensity measured on a Visual Analogue Scale (VAS) from 0-10 (from no expected pain to worst imaginable expected pain)

    Time frame: From beginning to end of experiment, approx. 45 minutes

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

En undersøgelse af Smerteoplevelsen Hos Raske forsøgsdeltagere (A Study of the Pain Experience in Healthy Participants)

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 24, 2024
Registry last updated
Sep 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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