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NCT Number: NCT07604220

Exosome-based Omic Signatures of Disease Activity in Cardiac Sarcoidosis (EXODACS)

The purpose of this study is to develop a prospective cohort of patients with and without cardiac sarcoidosis as well as active and inactive disease to develop a prospective biobank from which exosome analysis of peripheral blood will derive unique biomarkers of disease activity in cardiac sarcoidosis.

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Key information

Conditions

Cardiac Sarcoidosis Hemic and Lymphatic Diseases Hypersensitivity Hypersensitivity, Delayed Immune System Diseases Lymphatic Diseases Lymphoproliferative Disorders Sarcoidosis Sarcoidosis With Myocarditis Sarcoidosis of the Heart Sarcoidosis, Cardiac

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults ≥18 years.
  • Patients referred to the Cardiac Sarcoid Clinic with a clinical suspicion or a previously confirmed diagnosis of cardiac sarcoidosis.
  • Undergoing FDG-PET as part of standard care.
  • Ability to provide informed consent.

Exclusion criteria

  • Inability to provide informed consent.

Treatment and study plan

Exosome Analysis

Other

Blood Samples will undergo exosome profiling using mass spectrometry and/or other discovery-based approaches

Primary outcomes

  1. Number of successful biomarker validations

    Time frame: Baseline

    Biomarker validation will be defined as ability to discriminate active from inactive or quiescent disease as assessed by FDG-PET

Study contacts

Contact information is provided by the study sponsor or research team.

Anna Pick

CONTACT

[email protected]

507-255-0630

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Acronym: EXODACS

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 22, 2026
Registry last updated
May 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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