NCT Number: NCT07300332
The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D [25(OH)D] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.
Interested in participating?
Request Info35 year–50 year
All sexes
Interventional
Not applicable
Trikala, Karyes, 42100, Greece
Location status: Recruiting
Athanasios Z Jamurtas, PhD
CONTACT
Eytychia Giouvri, BSc
SUB_INVESTIGATOR
Ioannis G Fatouros, PhD
CONTACT
Thirty adults with overweight/obesity (both males and females) who will meet the inclusion criteria will be randomly assigned to either an Exercise group (n=15) or a Control group (n=15). The Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet. The Control group will receive a balanced diet but will not participate in exercise training. Both groups will provide a resting blood sample and undergo assessment of their body composition (via bioelectrical impedance analysis), daily dietary intake (via dietary recalls) and physical activity level (via accelerometry) at baseline (prior to intervention), 6 weeks and 12 weeks.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Receive a balanced diet and participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period
Receive a balanced diet but abstain from any type of exercise training
Time frame: At baseline, 6 weeks and 12 weeks
25-OH-VD will be quantitatively determined in serum
Time frame: At baseline, 6 weeks and 12 weeks
Vitamin D binding protein concentration will be determined in plasma
Time frame: At baseline, 6 weeks and 12 weeks
Calcium concentration will be determined in serum
Time frame: At baseline, 6 weeks and 12 weeks
Albumin concentration will be determined in serum
Time frame: At baseline, 6 weeks and 12 weeks
SGOT concentration will be determined in serum on a Clinical Chemistry analyzer
Time frame: At baseline, 6 weeks and 12 weeks
SGPT concentration will be determined in serum on a Clinical Chemistry analyzer
Time frame: At baseline, 6 weeks and 12 weeks
γ-GT concentration will be determined in serum on a Clinical Chemistry analyzer
Time frame: At baseline, 6 weeks and 12 weeks
Reduced glutathione concentration will be determined in blood erythrocytes
Time frame: At baseline, 6 weeks and 12 weeks
Oxidized glutathione concentration will be determined in blood erythrocytes
Time frame: At baseline, 6 weeks and 12 weeks
Dietary intake habits will be assessed through dietary recalls
Time frame: At baseline, 6 weeks and 12 weeks
Physical activity will be assessed via accelerometry
Time frame: At baseline, 6 weeks and 12 weeks
Body composistion will be assessed via bioelectrical impedance analysis (BIA)
Contact information is provided by the study sponsor or research team.
Dimitrios Draganidis, PhD
CONTACT
Ioannis G Fatouros, PhD
CONTACT
University of Thessaly
Other
The Impact of Hybrid-type High-intensity Interval Training on Vitamin D Metabolism in Adults With Overweight/Obesity
Acronym: Hybri-D
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