Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT04532814

Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Notify Me

Key information

Conditions

Upper Body Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity, Abdominal Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For the exercise studies of leg glucose uptake - "insulin sensitive" group:

  • Sedentary, normal weight, premenopausal women.
  • Sedentary, age-matched normal weight men.
  • Weight stable for two (2) months prior to study.
  • Willing to provide written, informed consent.
  • For the exercise studies of leg glucose uptake - "insulin resistant" group:

For the exercise studies of leg glucose uptake - "insulin resistant" group:

  • Upper body obese (UBO) premenopausal women.
  • Age-matched upper body obese (UBO) men.
  • Weight stable for two (2) months prior to study.
  • Willing to provide written, informed consent.

Exclusion criteria

  • Age < 18 or > 55 years (premenopausal women and age-matched men).
  • Use of glucose-lowering agents.
  • For female subjects: positive pregnancy test at the time of enrollment or study
  • History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
  • Active systemic illness or malignancy.
  • Symptomatic macrovascular or microvascular disease.

Treatment and study plan

Exercise

Other

Cycling 60% VO2 max

Primary outcomes

  1. Skeletal muscle glucose uptake

    Time frame: 1 hour

    Is exercise induced skeletal muscle glucose uptake different in obese compared to lean adults

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Registry information

Important dates

Study start
2020
Primary completion
2026
Study completion
2026
First posted
Aug 31, 2020
Registry last updated
Aug 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.