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NCT Number: NCT06083324

EXErcise Regimen Designed to Improve Functional Mobility, Body Composition, and Strength After Treatment for Cancer

This protocol seeks to analyze patient outcomes of the standard of care, monitored group exercise regimen of high-load resistance training and functional exercises with compound movements under close supervision on individuals who have been treated for cancer.

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Key information

Conditions

Cancer Behavior Motor Activity Neoplasms

Age range

20 year–89 year

Sex eligibility

All sexes

Study type

Observational

Primary location

AHN CI Exercise Oncology and Resiliency Center

Pittsburgh, Pennsylvania, 15202, United States

Location status: Recruiting

Location contact

Chris Peluso, BS

SUB_INVESTIGATOR

Colin E Champ, MD, CSCS

CONTACT

[email protected]

412-734-7605

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 20-89 years
  • Women of child-bearing potential must verbally confirm lack of pregnancy prior to enrollment. They should also consent to use adequate contraception during the course of the study.
  • Participants must be determined capable of engaging in resistance training by exercise personnel and/or study PI
  • Participants must complete an assessment by EOC staff and be determined safe to engage in the workout regimen by the study exercise personnel.
  • Individuals not deemed safe to participate in the standard EOC exercise program will be referred to physical therapy or elsewhere

Exclusion criteria

  • Severe arthritic, joint, cardiovascular, or musculoskeletal condition that would interfere with exercise program

Treatment and study plan

Dose escalated resistance training

Other

All individuals will be engaging in resistance training during and/or after their cancer treatment

Primary outcomes

  1. Determine changes in fat mass in pounds from before to after the nutrition and exercise regimen via bioimpedance analysis

    Time frame: 3 months

    Measurement on bioimpedance analysis machine (Inbody 970)

  2. Determine changes in fat mass in pounds from before to after the nutrition and exercise regimen via ultrasound

    Time frame: 3 months

    Measurement via ultrasound and calculation with Jackson-Pollack calculations

  3. Determine changes in muscle mass in pounds from before to after the nutrition and exercise regimen

    Time frame: 3 months

    Measurement on bioimpedance analysis machine (Inbody 970)

Secondary outcomes

  1. Determine changes in overall score of functional movement screen (FMS) from before to after the nutrition and exercise regimen

    Time frame: 3 months

    Determine changes in overall score of functional movement screen (FMS) from before to after the nutrition and exercise regimen

  2. Determine changes in Y-balance score for each leg

    Time frame: 3 months

    Y-balance score adds up the distance each leg can move in the front and side directions, divided by the length of the hip. This correlates inversely with fall risk.

  3. Determine changes in strength via load measured in pounds from before to after the nutrition and exercise regimen

    Time frame: 3 months

    Load is calculated by multiplying sets by repetitions by weight lifted for a specific exercise

  4. Determine changes in EQ-5D responses 1-5 and overall score from before to after the nutrition and exercise regimen

    Time frame: 3 months

    EQ-5D asks 5 questions rates from 1-5 and an overall rating of health

Study contacts

Contact information is provided by the study sponsor or research team.

Samantha Campbell

CONTACT

[email protected]

(412) 330-6151

Sponsors and collaborators

Lead sponsor

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

Other

Registry information

Official study title

EXERT-C: Prospective Study of an EXErcise Regimen Designed to Improve Functional Mobility, Body Composition, and Strength After Treatment for Cancer

Acronym: EXERT-C

Important dates

Study start
2023
Primary completion
2027
Study completion
2028
First posted
Oct 16, 2023
Registry last updated
Jul 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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