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NCT Number: NCT07458854

Exercise in Patients Undergoing Autologous Stem Cell Transplantation: A Randomized Controlled Trial

This interventional study assigns participants undergoing autologous hematopoietic stem cell transplantation to a supervised exercise program or usual care. The exercise program includes strength, endurance, and flexibility sessions for 8 weeks, 5 days per week. The control group receives usual care without a structured exercise program.

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Key information

Conditions

Hematologic Malignacy Autologous Hematopoietic Stem Cell Transplantation Behavior Motor Activity

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Erciyes University Faculty of Sport Science

Kayseri, 38039, Turkey (Türkiye)

About this study

This interventional study is conducted at Erciyes University Faculty of Medicine, Department of Hematology in patients scheduled for autologous hematopoietic stem cell transplantation. Eligible participants are assigned to either a supervised exercise program or usual care.

The exercise intervention consists of strength, endurance, and flexibility sessions performed five days per week for eight weeks under supervision. Participants in the control group receive standard medical care without a structured exercise program.

The study aims to examine the effects of the exercise program during the transplantation process in patients undergoing autologous stem cell transplantation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years, <65 years
  • Able to exercise at time of enrolment.
  • no methastasis

Exclusion criteria

- Unable to communicate or read in Turkish,

  • Contraindications to 3 T MRI (e.g., pacemaker or implanted metallic device).
  • co-morbid cardiac disease
  • painful joint

Treatment and study plan

Exercise Program

Behavioral

8-week structured strength, endurance and flexibility exercise program performed 5 days per week. Resistance intensity was determined using 1RM, aerobic intensity using Karvonen method (40-60%), monitored with Borg Scale

Primary outcomes

  1. Change in Handgrip Strength During the Transplantation Process

    Time frame: Baseline (4 weeks before transplantation),pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment 8(approximately 10-12 weeks total follow-up)

    Change in handgrip strength measured using a hand dynamometer at four time points: 4 weeks before transplantation, 2 days before transplantation, during the engraftment period, and 2 weeks after engraftment in patients undergoing autologous bone marrow transplantation.

Secondary outcomes

  1. Change in Back Strength

    Time frame: Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up).

    Back strength measured using a back dynamometer (kg) at four time points during the transplantation process.

  2. Change in Leg Strength

    Time frame: Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up).

    Leg strength measured using a leg dynamometer (kg) at four time points during the transplantation process.

  3. Change in Waist Flexibility

    Time frame: Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up).

    Waist flexibility assessed by sit-and-reach test (cm) at four time points during the transplantation process.

  4. Change in White Blood Cell Count

    Time frame: Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up).

    White blood cell count (10^9/L) obtained from routine complete blood count at four time points.

  5. Change in Neutrophil Count

    Time frame: Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up).

    Neutrophil count (10^9/L) obtained from routine complete blood count at four time points.

  6. Change in Lymphocyte Count

    Time frame: Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up).

    Lymphocyte count (10^9/L) obtained from routine complete blood count at four time points.

  7. Change in Platelet Count

    Time frame: Baseline (4 weeks before transplantation), pre-transplant (2 days before), during engraftment, and 2 weeks post-engraftment (approximately 10-12 weeks total follow-up).

    Platelet count (10^9/L) obtained from routine complete blood count at four time points.

Sponsors and collaborators

Lead sponsor

TC Erciyes University

Other

Registry information

Official study title

The Effect of Therapeutic Exercise in Patients Undergoing Autologous Stem Cell Transplantation: A Randomized Controlled Trial

Important dates

Study start
2014
Primary completion
2014
Study completion
2018
First posted
Mar 9, 2026
Registry last updated
Mar 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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