Exercise Facilitation of Adolescent Fear Extinction, Frontolimbic Circuitry, and Endocannabinoids

Inclusion criteria

• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and available for the duration of the study
• 14-17 years of age upon enrollment
• Right-handed
• In good general health as evidenced by medical history
• Adolescent and parent/guardian are English-speaking, as study assessments are in English
• Availability of a parent or legal guardian who is willing to provide consent and attend all study visits

Exclusion criteria

• Traumatic brain injury with ongoing symptoms
• Sensory (e.g., hearing) or physical (e.g., motor, balance) impairment or significant developmental delay
• MRI participants: MRI contraindication (e.g., braces, implants, claustrophobia)
• Any condition that would contraindicate blood draws (e.g., hemophilia, sickle cell)
• Past or current diagnosis or presence of likely neurological disorder (e.g., epilepsy), psychotic disorder (e.g., schizophrenia, schizoaffective disorder), or bipolar disorder
• Severe/unstable medical condition (e.g., diabetes, rheumatoid arthritis)
• Current (past 1-month) use of cannabis or cannabinoid products including CBD unless willing to stop for at least 4 weeks prior to entering the study
• Currently pregnant, lactating, or positive pregnancy test at screening visit
• Current homicidal thoughts or suicide attempt in the past year
• Current suicidal thoughts requiring immediate intervention
• Concurrent use (past 6 weeks) of oral contraceptives
• Diagnosed or probable substance use disorder (past 1-month)
• Positive drug test at baseline visit (e.g., THC, cocaine)
• Moderate/severe drug or alcohol use in the past 8 weeks
• Current or recent (past 1-month) COVID-19 diagnosis or febrile illness
• Treatment with investigational drug or intervention (past 1-month)
• Current smoker, vaper, or tobacco or nicotine use (past 1-month)
• Ongoing exposure to abuse