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OpenTrials
Active, Not Recruiting

NCT Number: NCT01176578

Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes

The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Type 2 Diabetes Mellitus Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Baltimore VA Medical Center

Baltimore, Maryland, 21201, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 50-80
  • Non-smoker
  • If woman, postmenopausal >1 year

Exclusion criteria

  • History of heart disease or stroke
  • Cancer
  • Poorly controlled hypertension or dyslipidemia
  • Kidney or Liver diseases

Treatment and study plan

Aerobic exercise training

Other

6 months of aerobic exercise training, 3 days per week

Primary outcomes

  1. Endothelial progenitor cell number

    Time frame: Baseline

  2. Endothelial progenitor cell number

    Time frame: 6-month

  3. Skeletal muscle capillarization

    Time frame: Baseline

  4. Skeletal muscle capillarization

    Time frame: 6-month

Secondary outcomes

  1. Cardiorespiratory Fitness

    Time frame: Baseline

  2. Cardiorespiratory Fitness

    Time frame: 6-month

Sponsors and collaborators

Lead sponsor

Baltimore VA Medical Center

Fed

Collaborators

  • University of Maryland, Baltimore

Registry information

Official study title

Exercise Training, CACs, and Vascular Function in Older Veterans With IGT (Impaired Glucose Tolerance)

Acronym: EPC-DM

Important dates

Study start
2011
Primary completion
2021
Study completion
2026
First posted
Aug 6, 2010
Registry last updated
Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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