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Completed

NCT Number: NCT05907460

EXecution of Trans-Esophagus Echo Cardiogram in CardioPulmonary Resuscitation for Patients With Out-of-hospital Cardiac Arrest

The purpose of this single center, randomized clinical control trial is to determine that changing chest compression site during cardiopulmonary resuscitation according to the examination of the TEE could increase the level of end-tidal CO2, which represents the quality of cardiopulmonary resuscitation, or not in adult patients with non-traumatic out-of-hospital cardiac arrest while comparing to those who don't receive examination of transesophageal echocardiography during cardiopulmonary resuscitation.

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Key information

Conditions

Out-Of-Hospital Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Far Eastern Memorial Hospital

Banqiao District, New Taipei City, 220, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 20 years-old
  • Out-of-hospital cardiac arrest
  • Non-trauma

Exclusion criteria

  • Obvious signs of death appears, such as separation of head and body, rigor mortis, livor mortis, cankered corpse......etc.
  • Family members clearly express the willing of do not attempt resuscitation or patients who have registered advance care planning not to attempt resuscitation.
  • Patients not suitable for transesophageal ultrasound, such as patients with esophageal tumor, those whose probe cannot be placed......etc.
  • Received Extracorporeal CPR.
  • Achieving sustained ROSC before ED arrival

Treatment and study plan

transesophageal echocardiography examination during cardiopulmonary resuscitation

Device

Perform transesophageal echocardiography in patients with out-of-hospital cardiac arrest during cardiopulmonary resuscitation and adjust the chest compression site to compress the left ventricle and avoid left ventricular outflow tract.

Primary outcomes

  1. Rate of sustained return of spontaneous circulation (ROSC)

    Time frame: 20 minutes after ROSC

    successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR) for at least 20 minutes

Secondary outcomes

  1. Rate of any return of spontaneous circulation

    Time frame: 1 minutes after ROSC

    successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR)

  2. Rate of survival to ICU admission

    Time frame: 48 hours after ROSC

    Successful restoration and stabilization of a patient's heartbeat and circulation, enabling safe transfer to the ICU.

  3. Rate of survival to discharge

    Time frame: 6 months after ROSC

    successful restoration and maintenance of a patient's heartbeat and blood circulation and able to complete treatment course till discharge

  4. Rate of discharge with favorable neurological outcomes

    Time frame: 6 months after ROSC

    using cerebral performance category score to measure neurologic outcomes of the patient at the time while patient's discharge. CPC1 and 2 are consider as favorable neurological outcomes, CPC3 and 4 are consider as unfavorable neurological outcomes

  5. end-tidal carbon dioxide (EtCO2)

    Time frame: During resuscitation

    measuring end-tidal carbon dioxide during resuscitation

Sponsors and collaborators

Lead sponsor

Far Eastern Memorial Hospital

Other

Registry information

Acronym: EXECT_CPR

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jun 18, 2023
Registry last updated
Oct 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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