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Active, Not Recruiting

NCT Number: NCT06845761

Examining the Relationship Between Ongoing Alcohol Use, Suicidal Thoughts and Behaviors and Related Constructs, and Behavioral Economic Decision-Making

The purpose of this single groups trial is to (Aim 1) determine relationships between alcohol use, suicidal thoughts and behaviors (STBs), and behavioral economic decision-making in a community sample (N = 100) of alcohol using adults who are 18 years of age or older, (Aim 2) is to determine factors that predict engagement with a remote intervention (computer based training for cognitive behavioral therapy; CBT4CBT) for alcohol and its effects on alcohol use, STBs, and decision-making with those same adults.

Participants will complete a baseline assessment and be given access for remote, self-guided CBT4CBT modules for alcohol use. Following this, participants will remotely complete three follow-up assessments over three months. This will allow for determination of incidence and predictors of alcohol use and STBs and determination of predictors of engagement and efficacy of a remote intervention for alcohol use in both samples.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Alcohol Use Alcohol Drinking Behavior Behavioral Symptoms Drinking Behavior Self-Injurious Behavior Suicidal Ideation Suicidal Ideation/Behavior Suicide

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Kentucky

Lexington, Kentucky, 40504, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • At least 18 years old
  • Consume alcohol at least weekly
  • A score of 8 or greater on the Alcohol Use Disorder Identification Test (AUDIT)
  • Some interest in cutting back on drinking or quitting
  • Read and understand English

Exclusion criteria

  • A score of 31 or greater on the Alcohol Use Disorder Identification Test (AUDIT) at baseline
  • Reporting schizophrenia and/or other psychiatric diagnoses other than depression or anxiety at baseline
  • Already being in treatment for alcohol use disorder at baseline
  • Past month substance use other than cannabis or tobacco

Treatment and study plan

Self-Guided Cognitive Behavioral Therapy

Behavioral

Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT) is a set of seven modules that consist of different skills trainings that can be accessed by devices with an internet connection. The version of CBT4CBT that will be provided is the alcohol-based CBT4CBT.

Other names: Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT)

Primary outcomes

  1. Change in Alcohol Use

    Time frame: Assessed at study week 0, 4, 8, and 12

    Participants will complete baseline and remote follow-up assessments. Alcohol use will be measured by timeline follow-back of alcohol use for the previous 4 weeks of time of assessment. General linear mixed-effects modeling will be used to assess changes in alcohol use.

  2. Engagement with Self-Guided Cognitive Behavioral Therapy for Alcohol Use

    Time frame: Assessed at study week 12

    At the end of the study, participant engagement with Computer Based Training for Cognitive Behavioral Therapy (CBT4CBT) modules will be analyzed with ordinary linear regression. Engagement will be defined as the proportion of modules completed.

  3. Change in Suicidal Thoughts and Behaviors

    Time frame: Assessed at study week 0, 4, 8, and 12

    Participants will complete baseline and remote follow-up assessments. Suicidal thoughts and behaviors will be will be measured by the Colombia Suicide Severity Rating Scale. Suicidal ideation severity is measured from a scale of 0 to 25, where higher scores indicate higher levels of suicidal ideation severity. General linear mixed-effects modeling will be used to assess changes in suicidal thoughts and behaviors.

Sponsors and collaborators

Lead sponsor

Mark J Rzeszutek, PhD

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 25, 2025
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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