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NCT Number: NCT07477210

Examine the Epidemiology and Outcomes of Transitions From PD-to-HD in Canada

Transitions from peritoneal dialysis to hemodialysis are common during kidney replacement therapy and may be associated with adverse outcomes. However, the incidence, predictors, and outcomes of PD-to-HD transitions at a national level remain incompletely characterized.

This study will use Canadian dialysis and hospitalization databases to examine the epidemiology and outcomes of PD-to-HD transitions among adults initiating dialysis in Canada. The study will evaluate transition incidence, predictors, and post-transition outcomes including mortality, transplantation, modality changes, and hospitalizations.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Peritoneal Dialysis (PD) Hemodialysis Kidney Replacement Therapy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CIUSSS de l'Est-de-l'ile de Montréal

Montreal, Quebec, H1T 2M4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (≥18 years)
  • Dialysis initiation in Canada between January 1, 2005 and December 31, 2018
  • Peritoneal dialysis duration >30 consecutive days

Exclusion criteria

  • Dialysis initiation in Quebec or Manitoba during the study period
  • Dialysis initiation in a foreign country
  • Missing data on initial dialysis modality
  • Pre-emptive kidney transplantation

Treatment and study plan

Primary outcomes

  1. Incidence of transfer from peritoneal dialysis to hemodialysis

    Time frame: From PD initiation until 1-year after PD start Also assessed at from PD initation until 2- and 5-year after PD start.

    Measured as cumulative incidence and incidence rate of transitions following initiation of PD and censored at time of death, kidney transplantation, transfer home hemodialysis, or administrative end of follow-up.

Secondary outcomes

  1. All-cause mortality after transfer from peritoneal dialysis to hemodialysis

    Time frame: From first day after transfer up to 1-year post transfert. Also assessed ad 2- and 5-year post transfer

    Censored for kidney transplantation, transfer home hemodialysis, return to PD or administrative end of follow-up December 31st, 2018

  2. Return to Peritoneal Dialysis

    Time frame: From first day after transfer to HD up to 180-day post transfer. Also measured at 90- and 365-day post transfer.

    Defined as ≥1 consecutive day of peritoneal dialysis after transition and censored at time of death, kidney transplantation, transfer home hemodialysis or administrative end of follow-up December 31st, 2018)

  3. Transfer to Home Hemodialysis

    Time frame: From first day after transfer to HD until 180-day post transfer. Also measured at 90- and 365-day post transfer

    Defined as ≥30 consecutive days of home hemodialysis censored at time of death, kidney transplantation, return to PD or administrative end of follow-up December 31st, 2018)

Sponsors and collaborators

Lead sponsor

Ciusss de L'Est de l'Île de Montréal

Other

Registry information

Official study title

Understand, Plan and Improve Care and Wellbeing of Patients at High Risk of Transfer From Peritoneal Dialysis to Hemodialysis, Epidemiology (Phase 1)

Acronym: UPLIFT-PD CORR

Important dates

Study start
2005
Primary completion
2019
Study completion
2027
First posted
Mar 17, 2026
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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