Skip to main content
OpenTrials
Completed

NCT Number: NCT07243353

Examination of the Effect of Nd:YAG Laser on Oxidative Stress and Matrix Metalloproteinase-9 in Teeth With Apical Periodontitis

The objective of this clinical investigation is to examine the impact of Nd:YAG laser therapy on oxidative stress and matrix metalloproteinase-9 (MMP-9) levels in teeth afflicted with apical periodontitis. Samples were collected from patients who had undergone treatment with the Nd:YAG laser and compared with samples collected from patients who had not received this treatment. The study commenced with a sample of 60 patients. However, the study was completed with 58 patients. The study concluded with the following finding: the use of Nd:YAG lasers was not found to be superior.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Apical Periodontitis Jaw Diseases Mouth Diseases Oxidative Stress Periapical Diseases Periapical Periodontitis Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

25 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Kırıkkale Üniversitesi Diş Hekimliği Fakültesi

Kirikkale, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged between 25 and 50 years and classified as American Society of Anesthesiologists (ASA) I. The maxillar and mandibular incisors and premolars with chronic apical periodontitis of a PAI score of 3 or 4 were included.

Exclusion criteria

  • Patients with American Society of Anesthesiologists (ASA) classification II or higher, pregnant, patients with localised or generalised periodontitis, patients who had used antibiotics in the last month and anti-inflammatory drugs in the last week, smokers, and teeth with internal or external root resorption, swelling, palpation pain or fistula in the relevant area, root fracture or incomplete root formation, and teeth that could not be isolated with rubber dam were not included in the study.

Treatment and study plan

Primary outcomes

  1. Measurement of TOS, TAOC and MMP-9 levels in periapical exudate and GCF

    Time frame: The initial and seventh days of the treatment period

    TOS, TAOC and MMP-9 levels were measured by ELISA in periapical exudate and GCF samples collected during routine root canal treatment in patients with apical periodontitis. No significant difference was detected in the change in biomarker levels between the group treated with the Nd:YAG laser and the control group.

Secondary outcomes

  1. Determination of the correlation relationship between TOS, TAOC and MMP-9 levels in periapical exudate and GCF samples

    Time frame: The initial and seventh days of the treatment period

    The present study investigated the correlation between periapical exudate and GCF samples. The findings revealed a unidirectional and strong relationship between TOS and TAOC.

Sponsors and collaborators

Lead sponsor

Kırıkkale University

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Nov 21, 2025
Registry last updated
Dec 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.