Skip to main content
OpenTrials
Completed

NCT Number: NCT07700394

Different Treatment Options For Mature Teeth With Apical Periodontitis

A randomized control trial which aim to compare the healing potential for the following treatment options for mature teeth with apical periodontitis:

Group I: Conventional root canal treatment (CRT) Group II: Regenerative endodontic treatment (RET) using a blood clot scaffold Group III: RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Apical Periodontitis Jaw Diseases Mouth Diseases Periapical Diseases Periapical Periodontitis Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of dentistry ain shams university

Cairo, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-30 years
  • Healthy patients with no systemic diseases or known allergic reactions
  • Mature permanent molars diagnosed with pulp necrosis
  • Presence of a medium sized periapical lesion confirmed clinically and radiographically (PAI=3,4,5)

Exclusion criteria

  • Patients with generalized chronic periodontitis
  • Presence of small periapical lesions (PAI=1,2)
  • Periodontal pockets > 3 mm
  • Presence of systemic diseases or known hypersensitivity to any material used in the study

Treatment and study plan

root canal treatment and intracanal medicament

Procedure

conventional root canal treatment with obturation

Regeneration

Procedure

Regeneration using induction of bleeding

Regeneration with BMPs

Procedure

RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)

Primary outcomes

  1. Healing in terms of volumetric change of lesion analyzed by CBCT

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Sara Tariq Elemam

Other

Registry information

Official study title

A Comparison Between Different Treatment Options For Mature Teeth With Apical Periodontitis: A Randomized Control Trial

Important dates

Study start
2021
Primary completion
2026
Study completion
2026
First posted
Jul 14, 2026
Registry last updated
Jul 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.