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NCT Number: NCT06742775

Evolution of the Relationship Between Central and Peripheral Arterial Wave Velocities as a Function of Age

Acquisition of synchronized cardiovascular signals from non-invasive measurements (ECG, photoplethysmography pulse sensors, inductance plethysmography) in healthy volunteers aged from 18 to 75, during spontaneous ventilation with apneas (20 seconds) for a total acquisition time of 30 minutes.

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Key information

Conditions

Aging Diagnostic Techniques, Cardiovascular

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women between 18 and 75 years of age
  • No acute cardiovascular pathologies less than 2 years old,
  • No chronic cardiovascular pathologies.
  • Stature compatible with the use of the plethysmography T-shirt.
  • Person affiliated to a social security scheme or beneficiary of such a scheme
  • Signed informed consent form

Exclusion criteria

  • Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons under psychiatric care under articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of article L. 1121-8, persons admitted to a health or social establishment for purposes other than research, minors, persons under legal protection or unable to express their consent).
  • Personnel with a hierarchical link to the principal investigator
  • Subjects excluded from another study,

Treatment and study plan

physiological signal acquisitions

Other

Subjects will be fitted with non-intrusive devices. In a semi-recumbent position, they will be asked to perform

  • 10 minutes of resting breathing
  • 10 cycles consisting of a 20-second apnea, to be performed at the end of inspiration, and 1 minute 40 of breathing (100 seconds).

This single participation session will last a total of one hour for the volunteer (equipment, recording, de-equipping), including 30 minutes of acquisition.

Primary outcomes

  1. Electrocardiogram

    Time frame: 1 hour

    acquisition of ECG signals

  2. Photoplethysmography

    Time frame: 1 hour

    acquisition of peripheral and central photoplethysmographic signals with radial, brachial, carotid and femoral sensors

  3. inductive plethysmography

    Time frame: 1 hour

    acquisition of abdominal and thoracic section variations with an inductive plethysmographic vest

Secondary outcomes

  1. link between peripheral and central pulse wave velocity

    Time frame: 1 hour

    Assesment of the link between peripheral and central vascular function with statistical analysis (Linear regression, Bland and Altman test)

Study contacts

Contact information is provided by the study sponsor or research team.

Stéphane TANGUY

CONTACT

[email protected]

+33476637117

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Collaborators

  • University Grenoble Alps

Registry information

Acronym: EvolVOAge

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Dec 19, 2024
Registry last updated
Dec 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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