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NCT Number: NCT07674680

Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women

To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.

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Key information

Conditions

Women Aging Menopause

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

University of Missouri

Columbia, Missouri, 65211, United States

Location contact

Jacqueline Limberg Associate Professor

CONTACT

[email protected]

1-573-882-2544

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy women,
  • Assigned female at birth,
  • 18-70 years of age,
  • Body mass index <18 or ≥30 kg/m2,

Exclusion criteria

  • Assigned male at birth,
  • Pregnancy,
  • Breastfeeding,
  • History of hormone replacement therapy, chemical menopause, or oophor-ectomy
  • Polycystic ovarian syndrome or Primary ovarian insufficiency,
  • Current smoking/Nicotine use,
  • Blood pressure ≥140/90 mmHg,
  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy,
  • Nerve/neurologic disease,
  • Cardiovascular, hepatic, renal, respiratory disease,
  • Hypersensitivity to nitroglycerin,
  • Diabetes,
  • Communication barriers,

Treatment and study plan

Placebo

Drug

Participants will receive a placebo in pill form.

Gemtesa

Drug

Participants will receive oral gemtesa (75 mg).

Primary outcomes

  1. Blood flow

    Time frame: Change from baseline to minute 2.

    Blood flow measured with Doppler ultrasound.

Study contacts

Contact information is provided by the study sponsor or research team.

Jacqueline Limberg Associate Professor

CONTACT

[email protected]

1-573-882-2544

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Registry information

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Jun 29, 2026
Registry last updated
Jul 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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