Evidence-based Screening Strategies for Celiac Disease

Main aim: To find evidence-based screening strategies for celiac disease in high risk groups and to find new biomarkers or biomarker combinations for celiac disease diagnostics and follow-up.

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Key information

Conditions

Celiac Disease Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Malabsorption Syndromes Metabolic Diseases Nutritional and Metabolic Diseases

Age range

6 month–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tampere University Hospital / Tampere University

Tampere, 33521, Finland

About this study

The current project will result in the identification of genetic, environmental or downstream biomedical markers that predict the development of celiac disease at the individual level. Moreover, the markers can be exploited in prediction of specific disease risks, manifestations, comorbidities and complications.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cohort 1: Family member of celiac disease patient
Cohort 2: Previously diagnosed celiac disease

Exclusion criteria

Cohort 1: No previous celiac disease
Cohort 2: Celiac disease diagnosis not confirmed

Treatment and study plan

Celiac disease antibody screening

Diagnostic Test

Observational parameters

Primary outcomes

Forthcoming celiac disease diagnosed by current diagnostic criteria

Time frame: With in 10 years

Assessed by positive transglutaminase antibodies, small bowel mucosal villous atrophy

Sponsors and collaborators

Lead sponsor

Katri Kaukinen

Other

Registry information

Official study title

Improving Case-finding Strategies for Celiac Disease in Family Members: a Follow-up Study

Important dates

Study start: 2017
Primary completion: 2023
Study completion: 2032
First posted: May 2, 2017
Registry last updated: Jan 19, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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