Enabling Microbiomics- Driven Personalized Nutrition

The goal of this observational research study is to determine how diet contributes to various gastrointestinal related conditions.

The main question investigators aim to answer is:

Are host genetics, diet, and microbiome all important determinants of GI disorders, and how their relative contribution varies among individuals and populations.

Enrolling by Invitation

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Key information

Conditions

Inflammatory Bowel Disease (IBD) Celiac Disease Colitis Colitis, Microscopic Colitis, Ulcerative Colonic Diseases Colonic Diseases, Functional Constipation Crohn Disease Crohn's Disease Diarrhea Digestive System Diseases Functional Dyspepsia Gastroenteritis Gastrointestinal Diseases Inflammatory Bowel Diseases Intestinal Diseases Irritable Bowel Syndrome Irritable Bowel Syndrome (IBS) Malabsorption Syndromes Metabolic Diseases Microbiome Microscopic Colitis Nutritional and Metabolic Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive UC - Ulcerative Colitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age greater than or equal to 18 years
Gastrointestinal patients with or without genomic sequencing results available for the following cohorts:

Inflammatory Bowel Disease (IBD)
Irritable Bowel Syndrome (IBS)
Crohn's Disease
Celiac Disease
Diarrhea
Constipation
Healthy age and sex matched controls with or without genomic sequencing results available

o Control is defined as patients without gastrointestinal disease or no symptoms at time of sampling

Able to provide written, informed consent
Participant has a smartphone device with access to internet connection

Exclusion criteria

Patients with cognitive impairment
Active use of antibiotics at the time of stool collection

Treatment and study plan

Primary outcomes

To Correlate Differences in Diet and Microbiome with Different GI Symptoms and Disease States

Time frame: From enrollment through study completion, an average of 1 year.

Investigators will prospectively follow the clinical course of the patients throughout the duration of the study. Patient health outcomes will be documented from their medical record while the study is actively enrolling or undergoing data analysis.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Enabling Microbiomics- Driven Personalized Nutrition (EMPOWER)

Acronym: EMPOWER

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2028
First posted: Oct 24, 2024
Registry last updated: Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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