Evaluation of the Venous Excess Ultrasound Score (VExUS) After Circulating Volume Modification in Children.

Venous overload has an impact on peripheral organ perfusion and on the short- and long-term prognosis of intensive care patients. The VExUS ultrasound score is a new tool whose parameters can be used to estimate this impact. This score was initially evaluated and validated on an adult population. ) In children, there is only one study looking at the use and applicability of this VExUS score, highlighting its feasibility in a paediatric population, as well as a possible correlation between elevated central venous pressure and altered renal Doppler (one of the score's components).

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Key information

Conditions

Blood Volume Expansion Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

1 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Toulouse

Toulouse, 31000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children aged between 1 and 18 years, receiving extrarenal purification with UF > 10 ml/kg, bleeding > 10 ml/kg or vascular filling > 10 ml/kg

Exclusion criteria

Refusal of the patient or opposition of one or both holders of parental authority.
Minors with parental authority.
Ultrafiltration time > 6h.
Curarized patient, known abnormality of the hepatorenal venous network.
Patient agitated or poor tolerance of the examination.
Parents under court protection, guardianship or curatorship.

Treatment and study plan

VExUS evaluation ultrasound

Other

VExUS evaluation by ultrasound will be performed before the filling/bleeding/cleaning procedure, and again after the procedure:

Inferior vena cava measurement in Time-Motion (TM) mode, 1-2 cm from the right atrial orifice.
Hepatic venous Doppler measurement in pulsed Doppler mode.
Renal vein Doppler measurement in pulsed Doppler mode. Each measurement is performed three times consecutively (to average the results), then the ultrasound measurements are compiled into a score according to the degree of doppler severity.

Primary outcomes

Change in VExUS score

Time frame: 10 minutes before en after the procedure of extrarenal purification, bloodletting or vascular filling

The correlation between ultrasound measurement of the VExUS score and the change in blood volume induced by extrarenal purification, bloodletting or vascular filling is studied. Ultrasound is performed before and after the procedure, each measure 3 times in succession, to establish the score.

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Official study title

Evaluation of the Venous Excess Ultrasound Score (VExUS) After Circulating Volume Modification in Children. VExUS-Mod

Acronym: VExUS-Mod

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Nov 19, 2024
Registry last updated: Jan 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed