Evaluation of the Effects of an Oral Supplementation Containing Hyaluronic Acid

Inclusion criteria

• Subject having signed an Informed Consent Form (ICF) before any trial related activity is carried out;
• Female subject;
• Subject aged 40 to 70 years inclusive at the time of signing the ICF;
• Subject with thin and dry lips;
• Subject with dry skin measured on the cheeks (corneometry < 50);
• Female subject of childbearing potential must use one of the reliable methods of contraception during the investigation and agree not to change it during the study;
• Subject willing and able to follow all the study procedures and restrictions and complete the whole study phase;
• Subject affiliated to a health social security system (according to French Law).

Exclusion criteria

• Female subject who is pregnant or who is breast feeding;
• Female subject of childbearing potential with positive urine pregnancy test at the study visit (Day 1);
• Women with a BMI ≤ 17 or ≥ 32 kg/cm²;
• Subject with any uncontrolled diseases such as diabetes, hypertension, hyperthyroidism or hypothyroidism;
• Presenting or having a history of eating disorder (e.g. anorexia, food allergy) or gastro-intestinal malabsorption such as celiac disease, Crohn's disease, lactose intolerance;
• Subject with an history of sleeve or bypass
• Subject with current participation in any other interventional clinical study, based on interview of the subject;
• Subject with known or suspected hypersensitivity to any component(s) of the investigational products or to any ingredients of the vehicles (i.e., excipients);
• Subject with skin abnormalities (e.g., scars, excessive hair, tattooing) or any dermatosis (e.g., psoriasis, eczema, acne vulgaris) on the face which could interfere with the study;
• Subject having applied any cosmetic product (care cream, lotion, body milk…) or drug on the face (except usual cleansing products) within one week before the study visit (Day 1);
• Subject impossible to contact in case of emergency;
• Subject who, in the opinion of the investigator, is unlikely to comply with the Clinical Study Protocol (e.g., alcoholism, drug dependency or psychotic state);
• Subject who is in an exclusion period in the National Biomedical Research Register of the French Ministry of Health at randomization;
• Subject who has been deprived of their freedom by administrative or legal decision, or who is under care of a guardian or legal guardianship, or subject hospitalized in a medical or social establishment for any reason.