Evaluation of Surfactant Protein B in the Differential Diagnostics of Dyspnea

Establishing new biochemical markers in the differential diagnostics and risk stratification in heterogeneous patient collectives is becoming more and more important. The markers should be objective, reliable, reproducible, quick and cost effective as well as specific and sensitive. Concerning the differential diagnostics of "dyspnea", NT-pro-BNP plays the most important role for the evaluation of a cardiac origin. However, a corresponding biochemical marker for pulmonary stress is lacking. The aim of the study at hand therefore was the evaluation of surfactant protein B in the differential diagnostics of pulmonary and cardiac diseases.

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Key information

Conditions

Dyspnea Cardiac Disease Cardiovascular Diseases Heart Diseases Lung Diseases Pathological Conditions, Signs and Symptoms Pulmonary Disease Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Universitaetsmedizin Mannheim

Mannheim, 68167, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients presenting with dyspnea and giving informed consent

Exclusion criteria

outpatients
lack or doubt of legal competence
indication for mechanical ventilation
pregnancy
palliative patients
CPAP/LTOT
BMI > 30 kg/m2
sepsis
anemia
dialysis

Treatment and study plan

Primary outcomes

Surfactant protein B serum levels

Time frame: Days 1, 3 and 7

Sponsors and collaborators

Lead sponsor

Universitätsmedizin Mannheim

Other

Collaborators

Roche Diagnostics GmbH

Registry information

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: Sep 9, 2010
Registry last updated: Jun 24, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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