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Completed

NCT Number: NCT03095378

Evaluation of Root Coverage by Connective Graft and Different Root Conditioning Methods

The aim of this study was to evaluate the effect of two root-conditioning agents used in conjunction with subepithelial connective graft technique on root coverage outcomes. One is citric acid plus tetracycline and the other is antimicrobial photodynamic therapy.

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Key information

Conditions

Gingival Recession Gingival Diseases Mouth Diseases Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bauru School of Dentistry

Bauru, São Paulo, 17012-901, Brazil

About this study

Citric acid plus tetracycline has properties of root surface decontamination, surface demineralization and exposure of collagen fibers.

Antimicrobial photodynamic therapy has been widely used in Periodontics to obtain reduction of periodontopathogenic bacteria with absence of systemic side effects and minimal bacterial resistance. Also, it has properties of root demineralization and exposure of collagen fibers. These properties may enhance root coverage in procedures of subepithelial connective graft.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Gingival recession - Miller's class I or II (2 to 5 mm of height) at least in one tooth
  • Indication of root coverage by dentin hypersensitivity or esthetic

Exclusion criteria

  • Smokers
  • Pregnancy
  • Systemic medication use that could impair wound healing or surgery procedure
  • Systemic diseases as diabetes, uncontrolled hypertension, coagulation diseases, kidney diseases.

Treatment and study plan

Control

Procedure

Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with scaling and root planing

citric acid plus tetracycline

Procedure

Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with citric acid plus tetracycline

antimicrobial photodynamic therapy

Procedure

Periodontal plastic surgery aiming root coverage by palatal connective tissue graft. Root treatment with antimicrobial photodynamic therapy

Primary outcomes

  1. Total root coverage measured with a periodontal probe in mm

    Time frame: one year

    Distance from cemento-enamel junction to gingival margin = 0 mm

Secondary outcomes

  1. Keratinized mucosa width measured with a periodontal probe in mm

    Time frame: one year

    Ideal if keratinized mucosa width > 5mm

  2. Dentin hypersensitivity measured by applying an air jet on teeth and patient fills up a visual analogue scale

    Time frame: one year

    Ideal if scale = 0

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

Evaluation of Root Coverage by Subepithelial Connective Graft Associated to Root Conditioning by Citric Acid Plus Tetracycline and Antimicrobial Photodynamic Therapy: A Randomized Clinical Trial

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Mar 29, 2017
Registry last updated
Mar 29, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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