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NCT Number: NCT07061002

Evaluation of Recruitment Effectiveness in Patients With Obstructive Sleep Apnea Syndrome Using Lung Ultrasound

Patients with obstructive sleep apnea syndrome are at higher risk for respiratory complications after surgery. Oxygen depletion and respiratory distress are common in patients with obstructive sleep apnea syndrome. In this study, the effectiveness of the recruitment maneuver applied in the postoperative period will be investigated via lung ultrasound. Recruitment is a technique performed to improve the oxygen levels of patients. Patients diagnosed with obstructive sleep apnea syndrome between the ages of 18-65 will be included in the study and anesthesia and surgical procedures will be followed. The aim of the study is to compare the pulmonary complication rates between patients who underwent recruitment and those who did not, and to examine the effects of factors such as age and gender on these complications via lung ultrasound.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul University-Cerrahpasa, Cerrahpasa Medicine of Faculty

Istanbul, 34153, Turkey (Türkiye)

About this study

The effect of the recruitment maneuver applied in the postoperative period on lung ventilation and atelectasis will be investigated via lung ultrasound. Recruitment is a technique performed to improve the oxygen levels of patients. Patients diagnosed with obstructive sleep apnea between the ages of 18-65 will be included in the study. The aim of the study is to compare atelectasis rates, pleural fascial fluid accumulation, lung compliance, pneumothorax findings between patients who underwent and did not undergo recruitment with lung ultrasound. In addition, to examine the effects of factors such as age and gender on these complications with lung ultrasound. Our study is a prospective, single-center, control group clinical trial to be conducted on patients diagnosed with obstructive sleep apnea syndrome (OSA). Patients between the ages of 18-65, classified as American Society of Anesthesia I-III, and diagnosed with Obstructive Sleep Apnea (polysomnography or STOP-BANG score ≥3) will be included in the study. Written informed consent will be obtained from the patients before the surgical procedure. Patients to be excluded from the study will include American Society of Anesthesia class IV and above patients, those with a history of neuromuscular disease, patients requiring cardiac surgery, and patients requiring urgent surgical intervention.

Patients will be randomly divided into three groups by computer-based program: Group 1: A fixed 5 cmH2O post expiratory positive end-expiratory pressure will be applied. Group 2: In addition to the fixed positive end-expiratory pressure, a recruitment maneuver will be performed at the end of surgery before extubation by giving 6 breaths with a tidal volume at 2 times the vital capacity, an inspiration/expiration ratio of 1/1, and a lung plateau pressure of < 35 cmH2O. Group 3: In addition to the fixed positive end-expiratory pressure, a recruitment maneuver will be performed at the end of surgery by giving 6 breaths in the right and left lateral decubitus positions before extubation. All patients' preoperative demographic data, apnea device usage, chest X-ray, total anesthesia duration, surgical duration, drugs used and their doses, ventilation parameters (tidal volume, positive end-expiratory pressure, airway peak pressure), fluid balance, surgical procedure type, patient position data will be recorded. Hemodynamic parameters, oxygen, respiratory exercise and bronchodilator requirements of patients taken to the recovery unit will be recorded. Lung A line and B line scores will be evaluated separately as 8 zones while performing lung ultrasonography of all patients. Plasm points, air bronchogram findings, pleural sliding movements will be recorded for each zone. In these follow-ups, saturation, hemodynamic parameters, respiratory exercise, bronchodilator requirement, intubation requirement, unplanned intensive care admission, hospital stay duration will also be recorded.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18-65
  • American Society of Anesthesia I-III
  • Patients with consent to participate
  • Patients with preoperative OSA diagnosis (polysomnography or STOP-BANG≥3)

Exclusion criteria

  • American Society of Anesthesia >IV
  • Patients planned for postoperative intensive care follow-up 3. Cardiac surgery
  • Anesthesia outside the operating room
  • History of neuromuscular disease
  • Emergency surgical application
  • Invasive airway surgeries (pharynx, larynx)
  • Lung surgeries (pneumonectomy, lobectomy, etc.) 9. Presence of pregnancy

Treatment and study plan

Lung Recruitment Maneuver

Other

Lung Recruitment Maneuver (LRM) is a method that allows the alveoli to reopen by applying high positive pressure in order to prevent or treat alveolar collapse (atelectasis) that develops during or after anesthesia. LRM improves oxygenation by increasing functional residual capacity. Clinical studies have shown that LRM increases oxygenation levels, reduces areas of atelectasis, and shortens hospital stay. In this study, the effects of different recruitment maneuvers on postoperative atelectasis will be evaluated. In this group, just before extubation, the patients in this group will be given 6 breaths with a tidal volume of 2 times the vital capacity, an inspiratory/expiratory ratio of 1/1 and a lung plateau pressure of < 35 cmH2O, and a recruitment maneuver will be performed at the end of the surgery.

Positional Lung Recruitment Maneuver

Other

Lung Recruitment Maneuver (LRM) is a method that allows the alveoli to reopen by applying high positive pressure in order to prevent or treat alveolar collapse (atelectasis) that develops during or after anesthesia. LRM improves oxygenation by increasing functional residual capacity. Clinical studies have shown that LRM increases oxygenation levels, reduces areas of atelectasis, and shortens the length of hospital stay. In this study, the effects of different recruitment maneuvers on postoperative atelectasis will be evaluated. Patients in this group will be placed in the right and then left lateral decubitus position before extubation at the end of surgery and a recruitment maneuver will be performed by giving 6 breaths in each position, with a tidal volume twice the vital capacity, a 1/1 inspiratory/expiratory ratio, and a lung plateau pressure < 35 cmH2O.

Primary outcomes

  1. pulmonary complications underwent recruitment maneuver

    Time frame: 10 minutes before the start of surgery until 10 minutes after the end of surgery

    The primary outcome of the study was to compare the pulmonary complication rates between patients who underwent the recruitment maneuver and those who did not by lung ultrasound. Pulmonary complications were assessed by using the modified lung ultrasound score (LUSS). Higher scores on the LUSS indicated more severe ventilation loss. The degree of deaeration was assessed from 0 to 3. , Less than 3 B lines; ≥3 B lines were rated as 1, greater than 5 and confluent B lines were rated as 2, and multiple confluent B lines separated by a thickened or irregular pleural line or multiple subpleural consolidations were rated as 3.

Secondary outcomes

  1. Pulmonary Complications with Different Recruitment Maneuver Techniques

    Time frame: 10 minutes before the start of surgery until 10 minutes after the end of surgery

    The secondary outcome is to compare the pulmonary complication rates between patients who received different recruitment maneuver techniques. To compare the postoperative pulmonary complication rates of parameters such as age, gender, and body mass index. Pulmonary complications will be assessed by performing the modified lung ultrasound score (LUSS). Higher scores on the LUSS indicate more severe ventilation loss. The degree of deaeration will be assessed from 0 to 3. , Less than 3 B lines; ≥3 B lines indicate 1, greater than 5 and confluent B lines indicate 2, and multiple confluent B lines separated by thickened or irregular pleural lines or multiple subpleural consolidations indicate 3.

Study contacts

Contact information is provided by the study sponsor or research team.

Ayse Cigdem Tutuncu, Professor Doctor

CONTACT

[email protected]

+905325920584

Munevver Kayhan, Lecturer Doctor

CONTACT

[email protected]

+905057983044

Sponsors and collaborators

Lead sponsor

Istanbul University - Cerrahpasa

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 11, 2025
Registry last updated
Jul 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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