Evaluation of QTc Interval by Continuous Holter ECG Recording in Antipsychotic Drug-treated Patients With Schizophrenia

Inclusion criteria

• Subjects will be males or females between 18 - 65 years of age.
• Patient subjects will have a definite diagnosis by DSM-IV criteria, schizophrenia, schizoaffective disorder, or bipolar disorder.
• Patient subjects are currently under treatment with any antipsychotic, any mood stabilizer, any antidepressant or any combination of the above at the therapeutic dose for at least 3 months.
• Patients have a history of taking the medications listed in item 3 as prescribed.
• The subjects must be able to provide written informed consent

Exclusion criteria

• Subjects with a DSM-IV diagnosis of substance dependence as defined by DSMN within three months prior to selection.
• Subjects who are currently taking other medications that have been shown to prolong the QTc, including tricyclic antidepressants (e.g. amitriptyline, imipramine, maprotiline), fluoroquinolones, or antiarrhythmics (e.g. quinidine, procainamide, amiodarone, sotalol).

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