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OpenTrials
Completed

NCT Number: NCT01876524

tRNS in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients

The purpose of this study is to study the efficacy and security of noninvasive brain stimulation as a new approach for patients with Substance Use Disorders (SUDs) plus other psychiatric conditions like ADHD, Schizophrenia, Bipolar disorder, etc.

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Key information

About this study

Background: There is an intimate relationship between addictive behaviors and other mental disorders, proven by clinical practice and many epidemiological studies, genetic and neuroscience. This gives risk to the diagnosis of Dual Pathology: an addiction and another mental disorder.

Functional neuroimaging studies have shown that anterior cingulate cortex is associated with substance´s dependence and craving. Transcranial random noise stimulation (tRNS) stimulates parts of the brain and can change it´s activity.

Researchers are interested in reduce cravings for substance dependence on patients with Dual Pathology using tRNS in anterior cingulate cortex.

Aims: To determine whether tRNS in anterior cingulate cortex can reduce craving over Dual Pathology patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • > 18 years old and less than 60 years
  • Best-practice diagnosed Dual Pathology
  • Diagnosed since at least two years prior to enrollment.
  • Abuse more than 2 Substances

ExclusionC riteria:

  • Serious visual and hearing loss
  • Brain injury following cranial trauma
  • Other neurological disorders like Parkinson, ME, headache, etc.
  • Birth trauma
  • Mental retardation
  • Pregnant

Treatment and study plan

transcranial random noise stimulation

Device

Random Noise Stimulation between 100 and 500 Hz and 400-500 microAmperes are applied over head in particular areas

Other names: tRNS, tES

Primary outcomes

  1. AMEN Questionnarie

    Time frame: Following patients during 3 months after Brain noninvasive estimulation

    100 Items Questionnarie subdivided in 5 subscales: basal ganglia, cingulate cortez, temporal cortex, prefrontal cortex and limbic system

  2. Emotional Visual Event Related Potentials

    Time frame: Following patients during 3 months after Brain noninvasive estimulation

    Emotional Visual Event Related Potentials responses (time courses and topographies) and ICA components related with them, identified by Mitsar 201M EEG Amplifier using EEGLab software [ Time Frame: brainwaves patterns following an array of visual stimuli (human faces) during a 22 min. examination ]

Secondary outcomes

  1. CAGE Adapted to Include Drugs (CAGE-AID)

    Time frame: Following 3 months after tRNS brain stimulation

    The CAGE-AID is a sensitive screen for alcohol and drug problems.

Sponsors and collaborators

Lead sponsor

Spanish Foundation for Neurometrics Development

Other

Registry information

Official study title

Transcranial Random Noise Stimulation in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients

Acronym: tRND&SUDs

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Jun 12, 2013
Registry last updated
May 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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