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OpenTrials
Completed

NCT Number: NCT06322589

Evaluation of Human Efficacy of SOD Like Super Drink

To assess the efficacy of SOD like Super Drink on anti-oxidant capacity, immuno regulation and skin for human

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Key information

Conditions

Dermatology

Age range

30 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

China Medical University of department of cosmeceutics

Taichung, 406040, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy adults aged between 30-65 years old

Exclusion criteria

  • Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder
  • Patients with diseases of the skin, liver, kidney.
  • Female who is pregnant or nursing or planning to become pregnant during the course of the study.
  • Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.
  • Students who are currently taking courses taught by the principal investigator of this trial.

Treatment and study plan

SOD like Super Drink

Dietary Supplement

consume 1 bottle per day

Other names: AVON SOD like Super Drink

Placebo drink

Dietary Supplement

consume 1 bottle per day

Primary outcomes

  1. the volume of skin wrinkles

    Time frame: Volume change from Baseline skin wrinkles at 8 weeks

    IRV full-face skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units

  2. the roughness of skin texture

    Time frame: Rating skin roughness from Baseline skin texture at 8 weeks

    IRV full-face skin analyzer was utilized to measure skin texture. Units: arbitrary units

  3. the change of skin elasticity

    Time frame: Change from Baseline skin elasticity at 8 weeks

    Cutometer® was utilized to measure skin elasticity. Units: arbitrary units

  4. the change of Total Anti-oxidative Capacity (TAC) of blood

    Time frame: Change from Baseline TAC at 8 weeks

    venous blood was sampled to measure TAC

  5. the change of Superoxide Dismutase (SOD) of blood

    Time frame: Change from Baseline SOD at 8 weeks

    venous blood was sampled to measure SOD

  6. the change of Glutathione S-transferase (GST) of blood

    Time frame: Change from Baseline GST at 8 weeks

    venous blood was sampled to measure GST

  7. the change of Glutathione (GSH) of blood

    Time frame: Change from Baseline GSH at 8 weeks

    venous blood was sampled to measure GSH

  8. the change of Malondialdehyde (MDA) of blood

    Time frame: Change from Baseline MDA at 8 weeks

    venous blood was sampled to measure MDA

  9. the change of immune-related cytokines of blood

    Time frame: Change from Baseline immune-related cytokines at 8 weeks

    venous blood was sampled to measure immune-related cytokines

Secondary outcomes

  1. the change of skin surface hydration

    Time frame: Change from Baseline skin surface hydration at 8 week

    Corneometer® CM 825 was utilized to measure skin surface hydration. Units: arbitrary units

  2. the change of skin Transepidermal Water Loss (TEWL)

    Time frame: Change from Baseline TEWL at 8 week

    Tewameter® TM 300 was utilized to measure TEWL. Units: arbitrary units

  3. the change of Skin Melanin Index

    Time frame: Change from Baseline skin Melanin Index at 8 week

    Mexameter® MX 18was utilized to measure Melanin Index. Units: arbitrary units

  4. the change of Skin Erythema Index

    Time frame: Change from Baseline skin Erythema Index at 8 week

    Mexameter® MX 18was utilized to measure skin Erythema Index. Units: arbitrary units

Other outcomes

  1. The change of liver function biomarkers (AST, ALT) of blood

    Time frame: Change from Baseline liver function biomarkers at 8 weeks

    Venous blood was sampled to measure liver function biomarkers

  2. The change of renal function biomarkers (creatinine, BUN) of blood

    Time frame: Change from Baseline renal function biomarkers at 8 weeks

    Venous blood was sampled to measure renal function biomarkers

  3. The change of self-assessment skin condition and immuno condition

    Time frame: Change from Baseline skin condition and immunol condition at 8 weeks

    A self-assessment questionnaire was collected to evaluate skin condition and immunol condition，As for the evalutation of skin condition ,the higher score the better；As for evaluation of immunol condition , the higher score the worse

Sponsors and collaborators

Lead sponsor

TCI Co., Ltd.

Industry

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Mar 21, 2024
Registry last updated
Dec 6, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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