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Completed

NCT Number: NCT06854419

Efficacy Evaluation of Blood Peach Extract and Rose Apple Extract on Skin

Evaluate the effects of blood peach extract drink and rose apple extract drink on enhancing hemoglobin and iron levels, and improving skin health.

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Key information

Conditions

Dermatology

Age range

20 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

China Medical University of Department of Cosmeceutics

Taichung, 406040, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adult females aged 20 to 65;
  • Preferably those with pale complexion or signs of iron deficiency anemia.

Exclusion criteria

  • Currently undergoing or having undergone any medical beauty treatments within the past month (including skincare, laser treatments, chemical peel, injections, or cosmetic surgery);
  • Outdoor workers (exposed to sunlight for more than 5 hours daily);
  • Pregnant, breastfeeding, or planning to become pregnant during the trial (self-reported);
  • Individuals with heart, liver, kidney, endocrine, or other significant organic diseases (self-reported);
  • Individuals who have undergone major surgery (according to medical history);
  • Long-term medication users;
  • Individuals with mental health disorders;
  • Those who are already regularly taking iron supplements;
  • Faculty or staff members who are currently enrolled in the principal investigator's courses.

Treatment and study plan

Placebo drink

Dietary Supplement

Take one bottle of the product every morning on an empty stomach

Blood Peach Extract Drink

Dietary Supplement

Take one bottle of the product every morning on an empty stomach

Rose Apple Extract Drink

Dietary Supplement

Take one bottle of the product every morning on an empty stomach

Primary outcomes

  1. the volume of skin wrinkles

    Time frame: Volume change from Baseline skin wrinkles at 8 weeks

    IRV full-face skin analyzer was utilized to measure skin wrinkles. Units: arbitrary units

  2. the roughness of skin texture

    Time frame: Rating skin roughness from Baseline skin texture at 8 weeks

    IRV full-face skin analyzer was utilized to measure skin texture. Units: arbitrary units

Secondary outcomes

  1. the change of skin elasticity

    Time frame: Change from Baseline skin elasticity at 8 weeks

    Cutometer® was utilized to measure skin elasticity. Units: arbitrary units

  2. the change of skin collagen density

    Time frame: Change from Baseline skin collagen density at 8 weeks

    Dermalab® Combo was utilized to measure skin collagen density. Units: arbitrary units

  3. the change of skin pores

    Time frame: Change from Baseline skin pores at 8 weeks

    IRV full-face skin analyzer was utilized to measure skin pores. Units: arbitrary units

  4. the change of skin tone

    Time frame: Change from Baseline skin tone at 8 weeks

    IRV full-face skin analyzer was utilized to measure skin tone. Units: arbitrary units

  5. the change of skin hydration

    Time frame: Change from Baseline skin hydration at 8 weeks

    Corneometer® was utilized to measure skin hydration. Units: arbitrary units

  6. the change of skin melanin/erythema index

    Time frame: Change from Baseline skin melanin/erythema index at 8 weeks

    Mexameter® was utilized to measure skin melanin/erythema index. Units: arbitrary units

  7. the change of skin redness

    Time frame: Change from Baseline skin redness at 8 weeks

    Colorimeter was utilized to measure skin redness. Units: arbitrary units

  8. the change of lip redness

    Time frame: Change from Baseline lip redness at 8 weeks

    Antera 3D® was utilized to measure lip redness. Units: arbitrary units

  9. the change of Red Blood Cells (RBC) Count of blood

    Time frame: Change from Baseline RBC count at 8 weeks

    venous blood was sampled to measure RBC count

  10. the change of hemoglobin level of blood

    Time frame: Change from Baseline hemoglobin level at 8 weeks

    venous blood was sampled to measure hemoglobin level

  11. the change of mean corpuscular volume (M.C.V) level of blood

    Time frame: Change from Baseline M.C.V level at 8 weeks

    venous blood was sampled to measure M.C.V level

  12. the change of mean corpuscular hemoglobin concentration (M.C.H.C) level of blood

    Time frame: Change from Baseline M.C.H.C level at 8 weeks

    venous blood was sampled to measure M.C.H.C level

  13. the change of ferrous level of blood

    Time frame: Change from Baseline ferrous level at 8 weeks

    venous blood was sampled to measure ferrous level

  14. the change of ferritin level of blood

    Time frame: Change from Baseline ferritin level at 8 weeks

    venous blood was sampled to measure ferritin level

  15. the change of Total Iron Binding Capacity (TIBC) level of blood

    Time frame: Change from Baseline TIBC level at 8 weeks

    venous blood was sampled to measure TIBC level

  16. the change of unsaturated iron-binding capacity (UIBC) level of blood

    Time frame: Change from Baseline UIBC level at 8 weeks

    venous blood was sampled to measure UIBC level

Other outcomes

  1. the change of liver function biomarkers (AST, ALT) of blood

    Time frame: change from Baseline liver function biomarkers at 8 weeks

    venous blood was sampled to measure liver function biomarkers

  2. the change of renal function biomarkers (creatinine, BUN) of blood

    Time frame: change from Baseline renal function biomarkers at 8 weeks

    venous blood was sampled to measure renal function biomarkers

  3. the change of fasting glucose level of blood

    Time frame: change from Baseline fasting glucose level at 8 weeks

    venous blood was sampled to measure fasting glucose level

  4. the change of Advanced glycation end products (AGEs) level of blood

    Time frame: change from Baseline AGEs level at 8 weeks

    venous blood was sampled to measure AGEs level

  5. The change of self-assessment skin and metabolic circulation condition

    Time frame: Change from Baseline skin and metabolic circulation condition at 8 weeks

    A self-assessment questionnaire was collected to evaluate skin and metabolic circulation condition. As for the evalutation of skin condition, the higher score the better; As for evaluation of metabolic circulation condition, the higher score the worse.

Sponsors and collaborators

Lead sponsor

TCI Co., Ltd.

Industry

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 3, 2025
Registry last updated
Jul 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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