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Completed

NCT Number: NCT00876473

Evaluation of Different Continuous Positive Airway Pressure (CPAP) Systems in Patients With Acute Respiratory Failure

The aim of this study is to evaluate the performance, the tolerability and the efficacy on gas-exchange of different CPAP (Continuous Positive Airway Pressure) systems.

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Key information

Conditions

Acute Respiratory Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Policlinico Hospital

Milan, Italy

About this study

Three CPAP systems are studied for each patient at the same level of PEEP: 1) continuous high-flow CPAP with fixed value PEEP valve; 2) continuous high-flow CPAP with Boussignac PEEP valve; 3) demand flow CPAP, supplied by a ventilator.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Intubated-tracheostomized subjects receiving CPAP during the weaning from invasive mechanical ventilation

Exclusion criteria

  • Hemodynamic instability
  • Barotrauma
  • Severe myopathy

Treatment and study plan

CPAP system

Procedure

Evaluating the effects of different CPAP systems on respiratory mechanics, respiratory effort and gas-exchange

CPAP systems:

Continuous high-flow CPAP with fixed value PEEP valve

Continuous high-flow CPAP with Boussignac valve

Demand flow CPAP supplied by ventilator

Primary outcomes

  1. Respiratory mechanics, work of breathing, end-expiratory lung volume (EELV) and gas exchange

    Time frame: 30 minutes

Secondary outcomes

  1. Comfort of breathing

    Time frame: 30 minutes

Sponsors and collaborators

Lead sponsor

Policlinico Hospital

Other

Registry information

Official study title

The CPAP in Patients Affected by Acute Respiratory Failure

Important dates

Study start
2009
Primary completion
2014
Study completion
2014
First posted
Apr 6, 2009
Registry last updated
Apr 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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