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NCT Number: NCT07269990

Evaluation of Bone Behavior in Maxillary Post-extractive Sites Treated With Guided Bone Regeneration (G.B.R.) Techniques in Alveolar Socket Preservation (A.S.P.) Procedures With Different Autologous and Heterologous Biomaterials.

The maxillary bone atrophies from traumatic, pathological events or related to physiological bone loss after tooth extraction, promoting a decrease in bone volume (vertical-horizontal) which has always been a crucial challenge for the clinician in order to obtain adequate rehabilitations prosthetics.

The results of bone loss induced aesthetic and functional difficulties in achieving surgical and prosthetic rehabilitation of the right dental implant.

Bone loss can be restored with autologous bone grafts and in large bone atrophy of the jaws require complex surgical techniques such as vascularized bone transplantation.

As an alternative to the reconstruction of the maxillary tissue, several surgical techniques have been promoted to prevent or minimize bone resorption through market biomaterials with or without the patient's autologous bone.

To reduce or counteract biological bone resorption, surgeons have promoted alveolar cavity preservation procedures (ASP) with autologous or heterologous graft materials.

Recently, several studies have been published to evaluate the use of demineralized dentin material derived from the extracted tooth to obtain new bone in the maxillary post-extraction site.

The aim of the study is to compare different types of biomaterials 4 months after application through the use of the alveolar socket preservation technique.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

University of Foggia

Foggia, 71122, Italy

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy patients.
  • Diagnosis of tooth extraction in the upper or lower jaw.
  • Preservation procedures necessary to preserve jawbone volume with Guided
  • Bone regeneration with autologous or heterologous biomaterials.

Exclusion criteria

  • Patients with high risk of receiving the intervention (pre-existing medical conditions/comorbidities/possible adverse events).
  • Patients with conditions that may interfere with the evaluation or confound the results. (e.g. they are already taking treatments)
  • Patients with refusal to participate, inability to provide data, or at high risk of loss to follow-up.
  • Patients with neoplastic pathologies.
  • Patients with Radio-Chemo therapies.

Treatment and study plan

compare different types of biomaterials 4 months after application through the use of ASP compare different types of biomaterials 4 months after application through the use of ASP Group 2

Procedure

The aim is to compare different types of biomaterials 4 months after application through the use of ASP in Group 1

Comparison of different types of biomaterials 4 months after application through the use of ASP

Procedure

The aim is to compare different types of biomaterials 4 months after application through the use of ASP in Group 2

Comparison different types of biomaterials 4 months after application through the use of ASP

Biological

The aim is to compare different types of biomaterials 4 months after application through the use of ASP in Group 3

The aim is to compare different types of biomaterials 4 months after application through the use of ASP

Procedure

The aim is to compare different types of biomaterials 4 months after application through the use of ASP in Group 4

Primary outcomes

  1. Comparison of different biomaterials at 4 months to assess the percentage of residual biomaterial remaining in situ and the percentage of newly formed bone in the regenerated area.

    Time frame: 4 months after surgery

Sponsors and collaborators

Lead sponsor

University of Foggia

Other

Registry information

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Dec 8, 2025
Registry last updated
Apr 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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