Evaluation of Adult Onset Still Disease Classification Criteria and Differential Diagnosis at Eighteen Months of Follow-up

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up of patients. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

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Key information

Conditions

Adult Onset Still Disease Arthritis Arthritis, Rheumatoid Autoimmune Diseases Connective Tissue Diseases Immune System Diseases Joint Diseases Musculoskeletal Diseases Rheumatic Diseases Skin and Connective Tissue Diseases Still's Disease, Adult-Onset

Age range

18 year and older

Study type

Observational

About this study

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Other conditions such as cancer, infection or other inflammatory disease might mimick its symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up after an initial diagnosis of AOSD. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adults
with glycosylated ferritin dosage for suspected adult onset still disease
with at least 18 month of follow-up

Exclusion criteria

known infectious disease
known cancer
known active connective tissue disease or vasculitis

Treatment and study plan

diagnosis criteria performance

Other

Primary outcomes

diagnosis performance of Yamaguchi and Fautrel criteria at 18 months of follow-up

Time frame: after 18 months of follow-up

Sensitivity, Specificity, positive predictive value, negative predictive value

Secondary outcomes

description of differential diagnosis mimicking adult onset still disease

Time frame: after 18 months of follow-up
identifying factors associated with the occurence of a differential diagnosis during follow-up

Time frame: after 18 months of follow-up

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Acronym: AOSD-DIF

Important dates

Study start: 2010
Primary completion: 2021
Study completion: 2021
First posted: Feb 11, 2021
Registry last updated: Feb 11, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed