Evaluation of a Non-Invasive Device for Early Detection of Atopic Dermatitis Flares

Atopic dermatitis (AD), also called eczema, is a skin condition associated with repeated periods of worsening symptoms known as flares. Researchers believe that changes in skin barrier function may occur before visible skin changes or symptoms develop. The investigational Nevisense Go device uses Electrical Impedance Spectroscopy (EIS), which measures electrical properties of the skin related to skin barrier function. Previous studies using EIS have shown associations between impedance measurements and skin barrier changes in AD. This study will collect EIS measurements from affected and unaffected skin over time to evaluate whether these measurements may help estimate the likelihood of AD flare onset before visible signs or symptoms occur. The study is observational because device measurements will not be used to guide participant treatment or clinical care during study participation.

Inclusion criteria

Participants may be eligible if they:

• Are 12 to 89 years old.
• Have been diagnosed with atopic dermatitis (eczema).
• Have had at least one atopic dermatitis flare within the past 2 months.
• Are willing and able to use the Nevisense Go device at home, complete an electronic symptom diary, and attend study visits.
• If currently using systemic treatment for atopic dermatitis, have been on the same treatment for at least 3 months and do not plan to change treatment during the study.

Exclusion criteria

Participants may not be eligible if they:

• Are unwilling or unable to avoid applying creams, lotions, ointments, or soap to measurement areas for 6 hours before measurements.
• Do not have suitable skin areas for study measurements.
• Have another skin condition that may affect study assessments.
• Are pregnant.