Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration

The purpose of this study is to determine if a new MR pulse sequence is accurate in determining how much iron is in the liver.

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Key information

Conditions

Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Digestive System Diseases Fibrosis Genetic Diseases, Inborn Iron Metabolism Disorders Iron Overload Liver Cirrhosis Liver Diseases Metabolic Diseases Metabolism, Inborn Errors Metal Metabolism, Inborn Errors Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

About this study

Quantification of liver iron requires liver biopsy and histological assessment. New rapid MR techniques allow determination of liver relaxation times that can be altered with increasing iron deposition. The purpose of this study is to compare the results obtained with MRI to liver biopsy and iron quantification in patients undergoing liver biopsy in the setting of hemochromatosis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Undergoing liver biopsy for suspected or known hemochromatosis
Undergoing liver biopsy for living-related liver donation evaluation

Exclusion criteria

Contraindication to MRI

Treatment and study plan

Primary outcomes

Accuracy of MR in quantifying liver iron

Time frame: one time point

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Important dates

Study start: 2003
Primary completion: 2011
Study completion: 2011
First posted: Jan 7, 2008
Registry last updated: Jan 22, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed