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OpenTrials
Completed

NCT Number: NCT06042608

Evaluating Intercostobrachial Nerve Block's Effect on Pain Control After Shoulder Replacement

Interscalene blocks are frequently performed to decrease postoperative pain after shoulder surgeries and are considered the gold standard for pain control after this type of surgery. Some patients report pain in the axilla (armpit) following shoulder replacement surgeries. Sensation in the axilla is supplied by nerves not covered by the interscalene block. Sensation in the axilla can be decreased by performing an intercostobrachial nerve block. This study aims to study whether adding an intercostobrachial nerve block to the interscalene block decreases recovery room stay time, opioid pain medication requirement, and postoperative pain scores.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients 18-80 years old
  • Adult patient's BMI <= 35
  • Individuals presenting for primary total shoulder arthroplasty or reverse total shoulder arthroplasty
  • Anticipated discharge home same day of surgery
  • Patient is able to provide informed consent to participate in the study.

Exclusion criteria

  • Patient presenting for revision shoulder surgery
  • Allergy to amide local anesthetic, liposomal bupivacaine or other medication involving liposomal formulation
  • Preexisting neurological deficits involving or potentially involving the ipsilateral brachial plexus
  • Preexisting contralateral vocal fold paralysis or recurrent laryngeal paralysis
  • Psychiatric or cognitive disorders that could interfere with perioperative evaluation including drug or alcohol abuse
  • Chronic pain conditions
  • Preoperative opioid use
  • Moderate to severe pulmonary disease
  • Moderate to severe sleep apnea
  • Planned postoperative admission.
  • Unplanned postoperative admission
  • Any contraindication to interscalene or intercostobrachial nerve block including any local disorder of the skin where blockade is to be performed which would prevent safe performance of the block
  • Any coagulation abnormality which would be a contraindication for block placement
  • Preoperative chronic renal dysfunction requiring renal replacement therapy or CrCl < 60
  • Sulfa allergy (or other reason patient cannot receive celecoxib)
  • Allergy or intolerance to any medication in the protocol
  • Body mass index >35
  • Pregnancy
  • Incarceration
  • ASA classification greater than 3
  • Inability to provide informed consent
  • Refusal to participate in the study

Treatment and study plan

intercostobrachial nerve block

Procedure

injection of local anesthetic to target the intercostobrachial nerve in the axilla

Primary outcomes

  1. time spent in PACU (recovery room)

    Time frame: 0-2 hours after surgery

  2. amount of opioid pain medications required to control postoperative pain

    Time frame: 0-3 days after surgery

Secondary outcomes

  1. pain scores (1-10 out of 10)

    Time frame: 0-3 days after surgery

Sponsors and collaborators

Lead sponsor

University of Texas Southwestern Medical Center

Other

Registry information

Official study title

Effect of Adding an Intercostobrachial Nerve Block to an Interscalene Block on Postoperative Pain After Total Shoulder Arthroplasty

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Sep 18, 2023
Registry last updated
Oct 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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