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NCT Number: NCT06866652

Evaluating Dyspnea in Autoimmune Myasthenia Gravis "Why am I Short of Breath?"

Individuals with MG (IwMG) experience shortness of breath that may be activity-related, occur at rest and even happen during sleep. Dyspnea is a complex, multidimensional and multifactorial symptom involving sensory perception, cognition and emotion. Identifying the cause(s) of dyspnea in MG may assist in finding therapeutic strategies, reducing discomfort, improving QoL and potentially limiting respiratory deterioration and incidence of MG crisis.

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Key information

Conditions

Myasthenia Gravis Autoimmune Diseases Autoimmune Diseases of the Nervous System Dyspnea Immune System Diseases Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Neurodegenerative Diseases Neuromuscular Diseases Neuromuscular Junction Diseases Paraneoplastic Syndromes Paraneoplastic Syndromes, Nervous System Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

MYaResp is a prospective observational, cross-sectional study to evaluate dyspnea in adults with autoimmune myasthenia gravis.

Study aims include to:

  • Describe the characteristics of dyspnea in IwMG
  • Understand contributing factors and factors associated with dyspnea in IwMG including the relationship between patient-reported dyspnea, disease severity and functional limitations.
  • Determine the most effective tests to identify the causes and contributing factors of dyspnea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18
  • Confirmed diagnosis of autoimmune MG
  • Shortness of breath in daily life: score 1 or 2 on the respiration item on the MG- activities of daily living score
  • Signed consent form
  • Affiliated to or beneficiary of a social security scheme

Exclusion criteria

  • Known Pregnancy
  • Known respiratory disorder (other than MG)
  • Recent (within past 4 weeks) respiratory infection
  • Current MG crisis or exacerbation (necessitating increase in MG medication &/or hospital admission)
  • No dyspnea - score 0 or 3 on the respiration item on the MG- activities of daily living score
  • Severe cognitive impairment/guardianship

Treatment and study plan

Primary outcomes

  1. Dyspnea questionnaires

    Time frame: baseline

    Dyspnea-12

Secondary outcomes

  1. cardiopulmonary exercise test

    Time frame: baseline

    cycle ergometer

  2. Polysomnography

    Time frame: baseline

    evaluation of sleep disordered breathing

  3. Functional measures

    Time frame: baseline

    6 minute walk test

  4. Quality of life questionnaires

    Time frame: baseline

    Revised version of the myasthenia gravis quality of life questionnaire (Burns, French validation Birnbaum)

  5. Anxiety and depression

    Time frame: baseline

    Hospital Anxiety and Depression Scale

Other outcomes

  1. impact of myasthenia in daily living

    Time frame: baseline

    impact of myasthenia in daily living score

  2. Respiratory pressures

    Time frame: baseline

    inspiratory and expiratory pressures

Sponsors and collaborators

Lead sponsor

Institut de Myologie, France

Other

Collaborators

  • APHP

Registry information

Acronym: MyaRESP

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Mar 10, 2025
Registry last updated
May 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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