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OpenTrials
Completed

NCT Number: NCT06955468

Evaluating a Bidirectional Priming Intervention for Goals-of-care Communication in Oncology

This pilot study will evaluate whether an intervention aimed at hospitalized patients with advanced lung and gastrointestinal cancers can help facilitate goals-of-care (GOC) communication with their oncologists after discharge.

While GOC communication is a recommended component of routine oncology care, many patients with solid cancers do not have the opportunity to talk with their oncologist about their goals and end-of-life preferences. Prior research has shown that a systematic method of prompting GOC communication with at-risk patients would address a key barrier to timely GOC communication and ensure that patients receive care that is in line with their personal preferences.

This trial will enroll 80 participants, who will be randomized 1:1 to either an intervention or a control group. Participants in the intervention group will complete a short survey regarding their goals, preferences, and disease understanding. Survey responses will be shared with each participant's outpatient oncology team. Oncologists will subsequently receive a nudge in the electronic medical record reminding them of key survey responses and encouraging them to discuss them at the patient's first clinic visit after hospital discharge.

The primary feasibility outcome is intervention completion rate and the primary clinical outcome is GOC documentation within 30 days of discharge in the intervention group compared to the control group.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Unplanned admission to the HUP Solid Oncology service;
  • Underlying diagnosis of advanced lung or GI cancer, defined as metastatic or locally advanced disease;
  • Anticipated discharge within the next 72h; and
  • Primary oncologist is based at HUP; or
  • Family member/caregiver of a patient meeting the above 4 criteria.

Exclusion criteria

  • Unable to complete survey in English.

Treatment and study plan

Priming Survey

Behavioral

13-item priming survey assessing patients' goals, treatment preferences, and disease understanding.

Primary outcomes

  1. Intervention Completion Rate

    Time frame: From enrollment to 30 days after hospital discharge

    The primary feasibility outcome is intervention completion rate, defined as successful completion of the survey, response sharing, and electronic medical record nudge for all participants assigned to the intervention arm.

  2. GOC Documentation

    Time frame: From enrollment to 30 days after hospital discharge

    The presence of outpatient goals-of-care documentation in the electronic medical record within 30 days of hospital discharge as determined by manual review.

Sponsors and collaborators

Lead sponsor

Abramson Cancer Center at Penn Medicine

Other

Collaborators

  • Conquer Cancer Foundation

Registry information

Official study title

Development of a Bidirectional Priming Intervention for Goals-of-care Communication in Oncology

Acronym: Prime GOC

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 2, 2025
Registry last updated
Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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