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Completed

NCT Number: NCT07064395

Bright Light Therapy on Sleep Health in Lung Cancer Patients

The goal of this randomized intervention trial is to determine the effect of bright light therapy on sleep disturbance, as well as to investigate the impacts of bright light therapy on biological age measured by clinical biomarkers. The main questions it aims to answer are:

* Does bright light therapy improve sleep patterns (i.e., sleep onset latency, sleep disturbance, and sleep efficiency) in lung cancer patients? * Can bright light therapy slow the rate of aging measured by biological age in lung cancer patients? Researchers will compare bright light therapy group to control group to see if bright light works to reduce sleep disturbance and decelerate biological aging.

Participants will:

* Receive bright light exposure or usual light exposure every day for 4 weeks * Get blood draw at the baseline and at 4 weeks for clinical biomarkers tests * Complete self-reported sleep, fatigue and stress surveys at the baseline and at 4 weeks * Keep a daily sleep log

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Key information

Conditions

Lung Cancers Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Henry Ford Health System

Detroit, Michigan, 48202, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • >=18 years of age
  • Stage Ib to IIIb primary lung cancer diagnosis
  • >=2 months after completion of primary therapy, patient can continue to be on maintenance/immunotherapy
  • ECOG performance status is 0 or 1
  • Experience problematic sleep (scores of >=8 on the Insomnia Severity Index)
  • Able to understand, speak, and read English
  • Sighted and mentally competent to consent

Exclusion criteria

  • Pregnant women
  • Have metastatic cancer
  • on oxygen therapy
  • Current diagnosis of seasonal affective disorder or substance abuse
  • Engage in shift work or travel across >3 time zones within 2 weeks prior to the study
  • Are currently being treated for sleep apnea, restless legs syndrome, or narcolepsy
  • Take prescribed sedative hypnotics or antipsychotics
  • Have eye conditions (glaucoma or retinal disease), problem triggered by bright light (e.g., migraine), or take photosensitizing medications (e.g., some porphyrin drugs, antipsychotics, antiarrhythmic agents)
  • Participants with an Insomnia Severity Index <8
  • Participants with cognitive impairment (sores of <3 mini-cog test)

Treatment and study plan

bright light

Other

Lung cancer patients in the bright light arm will receive 12,000 lux bright light through light visor for 4 weeks.

Primary outcomes

  1. Change from Baseline in sleep patterns at 4 weeks

    Time frame: from enrollment to the end of the intervention at 4 weeks

    Changes in sleep patterns will be assessed by sleep efficiency (e.g., duration of sleep in hours), sleep quality (e.g., number of sleep disturbance), and sleep onset latency (e.g., minutes of falling asleep).

  2. Changes from baseline in the measures of biological age at 4 weeks

    Time frame: From enrollment to the end of intervention at 4 weeks

    Participants have a lower rate of biological aging

Secondary outcomes

  1. Change from Baseline in the measure of fatigue and stress at 4 weeks

    Time frame: From enrollment to the end of intervention at 4 weeks

    Participants will achieve a response if they have lower level of fatigue and stress level at 4 weeks. Stress will be assessed by stress scale ranging from 0 to 40, and a higher score refers to worse stress level. Fatigue will be assessed by a fatigue score ranging from 0-40, and a higher scale means severe fatigue level.

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Collaborators

  • Michigan State University

Registry information

Official study title

Bright Light Therapy to Reduce Sleep Disturbance and Biological Aging in Lung Cancer Patients

Acronym: BLT

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 14, 2025
Registry last updated
Jul 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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