Evaluate the Performance of Genetic Amplification by Polymerase Chain Reaction (PCR) and the "Mannan Antigenemia and Antimannan Antibodies Couple as a Means of Diagnosis and a Marker of Follow-up in Invasive Candidiasis.

Inclusion criteria

• Patient informed about the study
• Patients aged at least 18 years admitted to a medical Intensive Care or general intensive care
• Patients with suspected invasive candidiasis - that is to say:
• Presenting persistent sepsis despite broad-spectrum antibiotherapy for at least 48 hours or targeted antibiotherapy for a documented bacterial infection (sepsis will be defined according to:

• the usual SIRS criteria, at least 2 of the following 4: temperature > 38°C or < 36°C, tachycardia > 90/min, respiratory rate > 20/min or blood pressure carbon dioxide (PaCO2 ) < 32 mmHg, leukocytosis > 12000/mm3 or < 4000/mm3 or > 10% of immature forms.
• Persistent hemodynamic instability (impossibility to significantly diminish catecholamine requirement, need for rapid vascular resuscitation > 1000 ml over the previous 24 hours)
• Candida score ≥ 3 with multifocal colonization
• Decision to initiate echinocandin therapy made by the clinician in charge of the patient

Exclusion criteria

• Treatment with echinocandin > 1 day in the week preceding inclusion
• Patients not covered by national health insurance
• Pregnant or breast-feeding women