Esophageal Motility and Airway Defenses Among Infants

Feeding difficulties and airway related consequences contribute significantly to the infant mortality and morbidity. Some of these problems may be dependent on neural control and muscular function. Prematurity, congenital anomalies and perinatal depression represent three important conditions in infants, that may have feeding and airway difficulties.Development of motility of the foregut and the adaptation during normal and disease in developing infants is unclear.

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Key information

Conditions

Infant, Premature, Diseases Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Infant, Newborn, Diseases Perinatal Asphyxia

Age range

2 week–6 month

Sex eligibility

All sexes

Study type

Observational

Primary location

Columbus Childrens Hospital

Columbus, Ohio, 43205, United States

About this study

With the aid of small clinical research funding from the NIDDK, in this proposal, we have developed methods to safely evaluate foregut motility in relation to breathing among high risk infants. We are using simultaneous esophageal motility studies, swallowing and respiratory measurements in this evaluation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Prematurely born infants, Infants with congenital foregut anomalies, Infants with perinatal asphyxia, Ability to maintain vital signs at study,

Exclusion criteria

No contraindication to enteral feeding

Sponsors and collaborators

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Nih

Collaborators

Children's National Research Institute

Registry information

Important dates

Study start: 2002
Primary completion: 2005
Study completion: 2005
First posted: Jun 6, 2003
Registry last updated: Oct 6, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed