Epigenetic Biomarkers for Alzheimer's Disease

Alzheimer's disease (AD) is a neurodegenerative disorder with no know cure. The pathogenesis of late onset AD (LOAD) is complex and multifactorial in nature, with multiple susceptibility genes and environmental factors at interplay.

The objective of this study is to improve our understanding of the risk factors of LOAD by conducting an epigenome wide study within patients of LOAD contrasted against their cognitively normal siblings.

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Key information

Conditions

Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Age range

50 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The Chinese University of Hong Kong

Hong Kong

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Sufficient Cantonese competency for cognitive test
Written informed consent given
Have at least one gender-matched cognitively normal sibling

Exclusion criteria

Subjects who refuse blood taking procedure
Do not have a reliable family/caregiver informant (personal contact at least once a month)

Treatment and study plan

Primary outcomes

DNA methylation

Time frame: 5 years
RNA-seq microbiome

Time frame: 5 years
Alzheimer's disease Assessment Scale-cognitive subscale (Adas-Cog)

Time frame: 5 years

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Collaborators

Hong Kong University of Science and Technology

Registry information

Official study title

Identification of Epigenetic Biomarkers for Alzheimer's Disease in Blood Using Epigenome-wide Analysis

Important dates

Study start: 2019
Primary completion: 2024
Study completion: 2024
First posted: Sep 9, 2019
Registry last updated: Apr 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed