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OpenTrials
Completed

NCT Number: NCT03967210

Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella sp Meningitis

Klebsiella pneumoniae is implicated in the occurrence of severe pneumonia. Most Klebsiella pneumoniae infections are associated with care and occur in patients with compromised immune defenses. More recently, cases of hepatic abscess and acute community meningitis related to strains of Klebsiella pneumoniae have been reported. The mortality of these infections is important, most often due to a delayed diagnosis. The poor prognostic factors reported in the literature for very low numbers are: advanced age, coma, septic shock, glyceryachia <10mg / dL and proteinuria> 750 mg / dL. In addition, no study has specifically focused on the factors of occurrence and factors associated with Klebsiella sp. Indeed, meningitis related to Klebsiella pneumoniae seems to be a rare but probably underestimated event whose risk factors, clinical presentation, microbiological are little known and the treatment modalities of this severe infection are not codified.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Brest, Brest, France

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Man or Woman whose age ≥ 18 years
  • Patient with meningitis Klebsiella sp., hospitalized in one of the hospitals of the Clinical Microbiology Group
  • Francophone patient

Exclusion criteria

  • Patient under tutorship or curatorship
  • Patient deprived of liberty
  • Patient under safeguard of justice
  • Patient opposing his participation

Treatment and study plan

Primary outcomes

  1. Characterize meningitis with Klebsiella pneumoniae

    Time frame: Day 1

    This corresponds to characterize Klebsiella pneumoniae meningitis, portal entry, secondary infection, associated antibiotic and associated therapies and the clinical course of patients.

Sponsors and collaborators

Lead sponsor

Fondation Hôpital Saint-Joseph

Other

Registry information

Acronym: KlebsieLCR

Important dates

Study start
2019
Primary completion
2019
Study completion
2020
First posted
May 30, 2019
Registry last updated
Aug 23, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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