Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments (CameraCue)

The overarching goals of this proposal are to 1) identify the network of brain regions specifically activated by personal smoking environment cues and 2) to evaluate the effects of exposure to these cues on smoke self-administration and subjective reactivity. The results of this study will inform the development of novel and more efficacious cue-exposures therapies targeted at helping smokers quit smoking and will provide novel mechanism information regarding the influence of environmental context on drug taking.

The investigator hypothesizes that cue-exposure treatments (CETs), in which drug use is prevented during exposure to drug cues (e.g. lit cigarette) have been of limited efficacy in part because they have not included cues representative of the contexts in which drug use occurs. By demonstrating that context cues have a differential and robust influence on brain and behavioral responses, we will have provided a substantial basis for including such stimuli in the context of treatment. At the same time, we will have identified novel mechanisms by which such stimuli promote continued drug use and relapse.

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Key information

Conditions

Smoking Behavior Healthy

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Duke University Medical Center

Durham, North Carolina, 27705, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

generally healthy
between the ages of 18 and 55
smoking an average of 5 cigarettes per day for at least one year
breath CO (carbon monoxide) level > 8 ppm (if ≤ 8 ppm, then NicAlert Strip > 2)
no interest in quitting smoking for the duration of time required for the experiment
right-handed as measured by a three-item scale used in our laboratory
ability to identify 4 personal smoking and 4 personal non-smoking places

Exclusion criteria

inability to attend all required experimental sessions
significant health problems
use of psychoactive medications
use of smokeless tobacco
current alcohol or drug abuse
use of illegal drugs as measured by urine drug screen
current use of nicotine replacement therapy or other smoking cessation treatment
presence of conditions that would make MRI unsafe (e.g., pacemaker)

Treatment and study plan

Quit Smoking 6 hours

Behavioral

participants will quit smoking 6 hours prior to the cue-exposure sessions

Quit Smoking 24 hours

Behavioral

participants will quit smoking 24 hours prior to the fMRI scan

Primary outcomes

Signal Change in Functional Magnetic Resonance Imaging (fMRI) BOLD Signal between Personal Environment Pictures Relative to Standard Environment Pictures

Time frame: following 24 hours of smoking abstinence

During fMRI scanning participants will view pictures of personal and standard smoking and non-smoking environments; and also pictures of smoking-related and non-smoking related objects

Sponsors and collaborators

Lead sponsor

Duke University

Other

Registry information

Official study title

Environments as Smoking Cues: Imaging Brain Substrates, Developing New Treatments

Important dates

Study start: 2012
Primary completion: 2014
Study completion: 2014
First posted: Apr 25, 2013
Registry last updated: Jan 31, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed