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Completed

NCT Number: NCT05805306

Entre Herman@s: Promoting Health Among Latino MSM

This is a randomized controlled trial with an attention placebo control group. The goal of this study is to decrease HIV incidence in Latino men who have sex with men by engaging their siblings in PrEP-use promotion. In the intervention arm, siblings will be trained to engage their gay brother in PrEP conversations. In the control arm, siblings will be trained to engage their gay brother in conversations about vaccines to prevent COVID, Hepatitis A/B, or MPOX.

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Key information

Conditions

HIV Infections Behavior Blood-Borne Infections Communicable Diseases Genital Diseases Homosexuality Immune System Diseases Immunologic Deficiency Syndromes Infections Lentivirus Infections RNA Virus Infections Retroviridae Infections Sexual Behavior Sexuality Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Urogenital Diseases Virus Diseases

Age range

18 year–39 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Charles R. Drew University of Medicine and Science

Los Angeles, California, 90059, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Latino Men Who Have Sex with Men

  • self-identify as Latino
  • identify as male
  • be <40 years old
  • report HIV-negative status
  • be willing to talk about MSM healthcare issues with a sibling
  • either (a) have never used PrEP or (b) stopped using PrEP at least 90 days ago
  • missing most recent COVID vaccine
  • missing Hepatitis (A or B) vaccines
  • missing Mpox vaccine
  • meet CDC's PrEP eligibility criteria (be HIV-negative; any male sex partner in the past six months; not in a monogamous partnership with a recently tested, HIV-negative man; and at least one of the following: any anal sex without condoms in past 6 months, any sexually-transmitted infection (STI) diagnosed or reported in past 6 months, or is in an ongoing sexual relationship with an HIV-positive male partner).

Exclusion criteria

Latino Men Who Have Sex with Men

  • are unable to provide consent or
  • they do not meet any of the criteria above

Inclusion criteria

Siblings

  • at least 18 years old
  • report a close relationship his/her LMSM brother <40 years old
  • be willing to talk about MSM healthcare issues with his/her LMSM brother

Exclusion criteria

Siblings

  • are unable to provide consent or
  • they do not meet any of the criteria above

Treatment and study plan

Entre Herman@s

Behavioral

The intervention unfolds as follows: (Week 1) the research team, Latino MSM, & sibling will all engage in a PrEP Conversation followed by an individual Sibling Training for siblings to learn communication strategies for promoting health behaviors; (Week 2) we will send siblings reminders and a link to motivational interviewing techniques; (Week 3) we will conduct brief Follow-ups with siblings to determine if their brother changed his behavior; (Week 4) we will send a reminder to Latino MSM that they will have a follow-up the following week; (Week 5) we will conduct 30-day Follow-up with Latino MSM to determine if there was uptake of the new behavior change; (Week 7) same as week 5 above; (Week 10) send siblings information on motivational interviewing; (Week 12) final follow-up for both Latino MSM and siblings.

Vaccines for Health

Behavioral

The intervention unfolds as follows: (Week 1) the research team, Latino MSM, & sibling will all engage in a Health Conversation about vaccines for COVID, Hep A/B, or MPOX, followed by an individual Sibling Training for siblings to learn communication strategies for promoting health behaviors; (Week 2) we will send siblings reminders and a link to motivational interviewing techniques; (Week 3) we will conduct brief Follow-ups with siblings to determine if their brother changed his behavior; (Week 4) we will send a reminder to Latino MSM that they will have a follow-up the following week; (Week 5) we will conduct 30-day Follow-up with Latino MSM to determine if there was uptake of the new behavior change; (Week 7) same as week 5 above; (Week 10) send siblings information on motivational interviewing; (Week 12) final follow-up for both Latino MSM and siblings.

Primary outcomes

  1. Number of participants that start using PrEP

    Time frame: 90 days

    This measures how many participants in the experiment group started taking PrEP (baseline = 0 participants).

    Tool: Pictures. Participants will submit a picture of their pill bottle to report PrEP use.

  2. Number of participants that get vaccinated

    Time frame: 90 days

    This measures whether participants in the control group decided to get vaccinated for COVID, Hep A/B, or MPOX.

    Tool: Pictures. Participants will submit a picture of their proof-of-vaccination card to report vaccination status.

Secondary outcomes

  1. Number of participants who increase their willingness to use PrEP

    Time frame: 90 days

    This measures whether participants progress along the stages of change (e.g., pre-contemplation, contemplation, action) in their willingness to try PrEP if it were available to them.

    Tool: Stages of Change questionnaire administered at baseline and 90 days.

  2. Number of participants who increase their willingness to get vaccinated

    Time frame: 90 days

    This measures whether participants progress along the stages of change (e.g., pre-contemplation, contemplation, action) in their willingness to get vaccinated against COVID, Hep A/B, or MPOX if it were available to them.

    Tool: Stages of Change questionnaire administered at baseline and 90 days.

Sponsors and collaborators

Lead sponsor

Charles Drew University of Medicine and Science

Other

Collaborators

  • National Institute on Minority Health and Health Disparities (NIMHD)
  • St. Johns Community Health

Registry information

Official study title

Promoting HIV PrEP Among MSM: a Randomized Control Trial - Aim 3

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Apr 10, 2023
Registry last updated
Apr 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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