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NCT Number: NCT03778944

Enhancing Renal Graft Function During Donor Anesthesia

Renal transplantation is now recognized as the treatment of choice for patients with end-stage renal disease. An optimum anesthetic regimen should enhance the function and perfusion of the transplanted kidney. The aim of this study is to assess & compare the effectiveness of 3 different modalities in this respect: Mannitol, Dopamine and adequate hydration.

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Key information

Conditions

Renal Failure Chronic Anesthesia Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Transplant;Failure,Kidney Urogenital Diseases Urologic Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • end-stage renal disease, for living-donor kidney transplantation

Exclusion criteria

  • severe cardiac or hepatic dysfunction
  • coagulopathy

Treatment and study plan

Mannitol infusion

Procedure

Infusion of Mannitol 20% at a dose of 0.5 mg/kg to the renal graft donor after induction of anesthesia over 15 minutes.

Dopamine infusion

Procedure

Infusion of Dopamine at a dose of 4 microg/kg/min to the renal graft donor after induction of anesthesia till ligation of the renal artery.

Adequate hydration

Procedure

Infusion of Ringer Acetate at a rate of 15 ml/kg/hr to the renal graft donor after induction of anesthesia till ligation of the renal artery.

Primary outcomes

  1. Post-operative creatinine clearance

    Time frame: 7 days

    Post-operative creatinine clearance level of the transplanted kidney graft is measured in ml/min

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed M Elbadawy, MD

CONTACT

[email protected]

01064249076 ext. +2

Nazmy E Seif, MD

CONTACT

[email protected]

01227400808 ext. +2

Sponsors and collaborators

Lead sponsor

Nazmy Edward Seif

Other

Registry information

Official study title

Renal Graft Functional Enhancement During Donor Anesthesia: A Comparative Study of 3 Modalities

Important dates

Study start
2018
Primary completion
2026
Study completion
2026
First posted
Dec 19, 2018
Registry last updated
Jan 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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