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NCT Number: NCT07522463

Enhancing Attention and Processing Speed Through Home-based Music Rehabilitation Program After Stroke in Malaysia

Stroke often leads to significant cognitive impairment, impacting quality of life. While existing rehabilitation options exist, there's a need for innovative, accessible, and patient-centered solutions. Research suggests music can engage multiple brain networks associated with sensory and motor processes, cognition, and affective regulation, potentially enhancing cognitive functions like attention and processing speed as well. Home-based interventions have also demonstrated positive impacts on rehabilitation adherence and outcomes. Building on this foundation, this study proposes to develop and pilot test a home-based musical rehabilitation program to improve attention and processing speed in Malaysian stroke survivors.

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Key information

Age range

55 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Stroke often leads to significant cognitive impairment, impacting quality of life. While existing rehabilitation options exist, there's a need for innovative, accessible, and patient-centered solutions. Research suggests music can engage multiple brain networks associated with sensory and motor processes, cognition, and affective regulation, potentially enhancing cognitive functions like attention and processing speed as well. Home-based interventions have also demonstrated positive impacts on rehabilitation adherence and outcomes.

Building on this foundation, this study proposes to develop and pilot test a home-based musical rehabilitation program to improve attention and processing speed in Malaysian stroke survivors. Using a randomized controlled trial, the program's feasibility and preliminary effectiveness will be evaluated. Participants will undergo cognitive assessments at baseline, post-intervention, and follow-up, complemented by qualitative data collection to understand patient experience.

The anticipated outcomes include a culturally relevant, accessible home-based program tailored for Malaysian stroke survivors, preliminary evidence on the program's impact on attention and processing speed, insights into its feasibility and acceptability, and a foundation for a larger-scale randomized controlled trial. This research has the potential to transform stroke rehabilitation in Malaysia by offering an innovative, patient-centered approach that utilizes music therapy to enhance cognitive recovery and improve quality of life.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with ischemic or haemorrhagic stroke confirmed by CT scan
  • 18 to 70 years old
  • Duration of stroke within the first one year
  • Ability to provide informed consent
  • Understands Bahasa Melayu or English with basic communication abilities to follow instructions during therapy sessions
  • Mild to moderate cognitive impairments with MoCA score of 10-25, with incomplete score for the attention sections
  • Availability of caregiver (formal or informal) who can assist in the music therapy, monitor and give feedback during the music therapy sessions at home
  • Have one normal functioning hand to perform the movements during the music therapy rehabilitation program
  • Have good balance and able to sit upright

Exclusion criteria

  • Severe aphasia
  • Significant uncorrected hearing or visual impairments preventing engagement in music therapy.
  • Severe or unstable medical conditions (e.g., uncontrolled hypertension or diabetes).
  • Medications that significantly impair cognition or motor function (e.g., high-dose sedatives).
  • History of neurological diseases other than stroke (eg, Parkinson's disease).

Treatment and study plan

Musical Home-based Rehabilitation Program

Other
  • A certified music therapist will conduct an initial assessment (at the hospital or at your home if travel is not feasible).
  • You and your caregiver will receive structured training so you can carry out the programme at home independently.
  • You will complete home sessions of about 40 minutes per session, daily for 5 days per week, for 4 weeks.
  • Your caregiver will use a simple checklist after each session to record completion, duration, alertness, fatigue, and any concerns.
  • The therapist will make weekly phone calls to support adherence and address questions.
  • The therapist will conduct level checks approximately after 2 weeks (at hospital or at home) and may adjust the song tasks to match your progress.

Control Group (Standard Care)

Other
  • You will continue with the standard neurorehabilitation programme as prescribed by your rehabilitation team.
  • You will not take part in the home-based music therapy programme.

Primary outcomes

  1. Montreal Cognitive Assessment (MoCA)

    Time frame: 4 months

    The Montreal Cognitive Assessment (MoCA) is a widely used cognitive screening tool designed to detect mild cognitive impairment. It demonstrates higher sensitivity in identifying subtle cognitive deficits compared to other screening instruments.

    Scale Range: 0 to 30 Interpretation: Higher scores indicate better cognitive function Cut-off Score: A score of 26 and above is generally considered normal cognitive function

  2. Trail Making Test (TMT A and B)

    Time frame: 4 months

    Trail Making Tests are tests of speed for attention, sequencing, mental flexibility, visual search, and motor function.

  3. Digit Span (Forward and Backward)

    Time frame: 4 months

    Forward Digit Span (FDS) assesses short-term, auditory memory, while Backward Digit Span (BDS) tests working memory and central executive processing.

  4. Clock Drawing Test (CDT)

    Time frame: 4 months

    The Clock Drawing Test (CDT) is a quick,, widely used neurocognitive screening tool designed to detect dementia, Alzheimer's, and other cognitive impairments.

Secondary outcomes

  1. Cogniplus software for Reaction Time and Attention tests

    Time frame: 4 months

    CogniPlus is a computer-based cognitive training and assessment system developed to measure and improve attention, processing speed, and executive functions, particularly in individuals with cognitive impairments following stroke or other neurological conditions.

    Scale Range: Varies by subtest/module (e.g., attention, processing speed), typically reported as performance scores such as reaction time (milliseconds), accuracy (%), or standardized scores

    Interpretation:

    Higher accuracy (%) and standardized scores indicate better cognitive performance Lower reaction time (milliseconds) indicates better processing speed Outcome Metrics: Task-specific measures including reaction time, error rate, and level progression

Study contacts

Contact information is provided by the study sponsor or research team.

MAZLINA BINTI MAZLAN, MBBS

CONTACT

[email protected]

+60379675181

NIK SHERINA HAIDI BT HANAFI HANAFI, MBBS

CONTACT

[email protected]

+60379492802

Sponsors and collaborators

Lead sponsor

University of Malaya

Other

Registry information

Official study title

Enhancing Attention and Processing Speed Through Home-based Music Rehabilitation Program After Stroke in Malaysia: A Feasibility Random Controlled Study

Acronym: HMRPAS

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 13, 2026
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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