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Completed

NCT Number: NCT00988299

Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise)

In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:

1. decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise; 2. increase in resting metabolic rate 48 hours after exercise; 3. increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise; 4. decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.

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Key information

Conditions

Aging Behavior Motor Activity

Age range

60 year–75 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women
  • Age 60-75 years
  • normal weight
  • Weight-stable (± 5%) within the previous 3 months
  • Non-smoking for last year
  • Able to provide own transportation to study visits
  • Not currently involved in any other research study
  • Willing and able to participate in all aspects of the trial including research testing
  • Willing to give informed consent to participate

Exclusion criteria

  • Self-reported significant cardiovascular disease
  • Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
  • Medications known to affect exercise performance or metabolism
  • Excess caffeine use (> 500mg/day)
  • Any self-reported contraindications to exercise
  • Clinical depression
  • Abnormal cognitive function -

Treatment and study plan

Exercise

Other

exercise sessions at 45% and 60% of maximum effort

Primary outcomes

  1. non-exercise activity calorie expenditure

    Time frame: 2 days after exercise sessions

Secondary outcomes

  1. resting metabolic rate

    Time frame: 2 days after exercise sessions

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Collaborators

  • National Institute on Aging (NIA)

Registry information

Official study title

Energy Expenditure Responses to Acute Exercise in Older Women

Acronym: CEE

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
Oct 2, 2009
Registry last updated
Dec 6, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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