Endocan, VEGF and TNF-alpha Levels in Periodontal Disease and After Treatment

The primer aim of the study was to determine serum and gingival crevicular fluid (GCF) endocan levels in periodontal diseases pathogenesis supported with vascular endothelial growth factor (VEGF) and tumor necrosis factor alpha (TNF-α) levels.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Periodontal Disease Mouth Diseases Periodontal Diseases Stomatognathic Diseases

Age range

25 year–49 year

Sex eligibility

All sexes

Study type

Observational

About this study

The study consist of three groups: periodontally healthy individuals (group 1; n = 20), individuals with generalized chronic periodontitis (group 2; n = 20), the same patients with chronic periodontitis after they had been treated with scaling and root planing (SRP) were considered as Group 3. Clinical measurements were recorded; GCF and serum samples were obtained from each participant before and 6 weeks after therapy. Endocan, VEGF-A and TNF-α levels were measured by enzyme-linked immunosorbent assay.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Group 1 Inclusion Criteria:

No bone and attachment loss,
GI=0, PPD≤3mm, CAL≤3mm
Systematically healthy patients

Group 2 Inclusion Criteria:

GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically.
Systematically healthy patients

Exclusion criteria

Aggressive Periodontitis,
Oral pathologies,
Patients with any other systemic diseases,
Pregnant women and those in the lactation period,
Patients with smoking habit and taking medication
Patients received periodontal therapy in last 6 months

Treatment and study plan

Non-surgical periodontal treatment

Procedure

Non-surgical periodontal therapy is an anti-infective therapy which includes both mechanical and chemotherapeutic approaches to minimize or eliminate microbial biofilm, the primary etiology of gingivitis and periodontitis

Primary outcomes

Endocan levels

Time frame: 6 weeks

Change after periodontal treatment

Secondary outcomes

VEGF levels

Time frame: 6 weeks

Change after periodontal treatment
TNF-alpha levels

Time frame: 6 weeks

Change after periodontal treatment

Sponsors and collaborators

Lead sponsor

Bulent Ecevit University

Other

Registry information

Official study title

Effect of Non-surgical Periodontal Treatment on Gingival Crevicular Fluid and Serum Endocan, Vascular Endothelial Growth Factor-A and Tumor Necrosis Factor Alpha Levels

Important dates

Study start: 2015
Primary completion: 2015
Study completion: 2016
First posted: Apr 26, 2016
Registry last updated: Apr 26, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed