End-Tidal CO2 (ETCO2) Trends in Out-of-Hospital Cardiac Arrest

The investigators aim to assess the relationship between patient characteristics, prehospital treatments, and vital signs to determine if a threshold EtCO2 value, a change in EtCO2 value (final - initial), or a trend in EtCO2 (positive/negative) is a better predictor of patient survival to discharge. The secondary aim of this project is to identify significant predictors of neurologically intact patient survival as indicated by a cerebral performance category (CPC) score of 1-2.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Prehospital Resuscitation Cardiac Arrest, Out-Of-Hospital Cardiovascular Diseases End-Tidal Carbon Dioxide Heart Arrest Heart Diseases Out-of-Hospital Cardiac Arrest Prehospital Emergency Medical Services

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Office of the Medical Director of EMS for Metropolitan Oklahoma City and Tulsa

Oklahoma City, Oklahoma, 73135, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

EHR's resulting from 9-1-1 response
Adult patients (aged 18+ at time of cardiac event)
experiencing out-of-hospital cardiac arrest (OHCA)
transported by an agency under OMD oversight
must have at least 2 EtCO2 values captured during care Exclusion Criteria
EHR's resulting from inter-facility scheduled or unscheduled medical transfers
pediatric patients (those aged <18 at time of incident) or unknown age
ROSC obtained prior to arrival of EMS
insufficient vital sign data

Treatment and study plan

Primary outcomes

Survival to Hospital Discharge

Time frame: 90 days

lack of terminiation of CPR during prehospital or in hospital care

Secondary outcomes

Neurologically Intact Patient Survival

Time frame: 90 days

Based on Gasgow-Pittsburgh Cerebral Performance Category (CPC) score which ranges from 1 (best) to 5 (worst). Neurologically intact is defined as a score of 1-2 among survivors

Sponsors and collaborators

Lead sponsor

Office of the Medical Director for EMS in Oklahoma City and Tulsa

Other

Collaborators

Medtronic

Registry information

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2026
First posted: Jun 8, 2026
Registry last updated: Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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