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NCT Number: NCT07741955

Empowering Veterans in Research Effectively Using Virtual Engagement Tools

Cardiovascular disease is the leading cause of death among Veterans. Clinical trials are essential for developing better treatments, but Veterans remain underrepresented in these studies due to barriers including limited health literacy, lack of awareness, and mistrust. Current outreach approaches rely on either in-person physician conversations, which are limited by workforce constraints, or mailed letter invitations, which often fail to engage Veterans with limited health literacy. This study tests whether AI-generated video avatars can improve Veteran engagement in cardiovascular clinical trials.

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Key information

Conditions

Atrial Fibrillation (AF) Arrhythmias, Cardiac Atrial Fibrillation Behavior Cardiovascular Diseases Health Behavior Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Patient Acceptance of Health Care Patient Participation Treatment Adherence and Compliance

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Recent advances in artificial intelligence now enable the creation of personalized video avatars at negligible cost and time. These computer-generated videos can be rapidly adapted to describe any clinical trial and tailored to individual patient preferences in both speaker appearance and content.

The EVERYVET Study (Empowering VEterans in Research effectivelY using Virtual Engagement Tools) will evaluate whether these AI-supported tools can increase Veteran engagement in cardiovascular clinical trials compared to standard mailed letter invitations. The avatar invitations will be randomly embedded into outgoing invitations for existing VA clinical studies. Veterans will be able to choose their preferred avatar speaker from a diverse set of computer-generated Veteran and physician avatars and self-select the content topics most important to them. The study is co-designed with the Veterans and Family Research Engagement Council (VFREC) and a Veteran Co-Investigator to ensure the approach centers Veteran priorities and preferences throughout.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(Aim 2):

  • Age 65 years or older
  • CHA2DS2-VASc Score of 3 or greater
  • Veteran receiving care within the VA Health Care System
  • Eligible to receive a mailed invitation through the parent VA Cooperative Studies cardiovascular trial recruitment process

Exclusion criteria

(Aim 2):

  • Any exclusion criterion applied by the parent VA Cooperative Studies cardiovascular trial
  • Documented preference to opt out of VA research mailings

Inclusion criteria

(Aim 1 Qualitative Interviews):

  • Age 18 years or older
  • Veteran receiving care at VAPAHCS
  • Recently invited (within 3 months) to participate in an existing cardiovascular clinical trial at VAPAHCS
  • Able to provide informed consent in English

Exclusion criteria

(Aim 1 Qualitative Interviews):

  • Cognitive impairment documented in the electronic health record
  • Inability to communicate in English at a level sufficient for qualitative interview participation

Inclusion criteria

(Aim 1 Beta-Testing and Aim 3):

  • Age 18 years or older
  • Veteran receiving care at VAPAHCS or a participating VA-CTC site
  • Able to view a brief video and complete a short survey in English

Exclusion criteria

(Aim 1 Beta-Testing and Aim 3):

  • Inability to communicate in English at a level sufficient for survey completion

Inclusion criteria

(Focus Groups):

  • VA study coordinator or trial investigator actively engaged in cardiovascular clinical trial recruitment at VAPAHCS or a VA-CTC site
  • Willing to participate in a 60-90 minute virtual focus group

Treatment and study plan

AI-Generated Avatar Videos and Chatbot for Clinical Trial Outreach

Behavioral

Veterans randomized to the intervention arm will receive the website link where they can select their preferred Veteran avatar speaker from a diverse set of options and self-select content topics of interest. They may watch the self-directed tailored video to guide their decision to participate in the parent trial.

Other names: AI-Supported Patient Engagement Tool

Primary outcomes

  1. Proportion of Veterans who enroll in the parent VA Cooperative Studies cardiovascular trial within 6 months of receiving the invitation

    Time frame: Baseline through 6 months

    Superiority of enrollment rate in the intervention arm (AI-supported avatar invitation) compared to the control arm (routine letter invitation alone), assessed using an intention-to-treat approach.

Secondary outcomes

  1. Proportion of Veterans accessing the intervention website

    Time frame: Baseline through 6 months

    Process measure assessing engagement with the QR code and URL among Veterans randomized to the intervention arm.

  2. Proportion of Veterans viewing avatar videos

    Time frame: Baseline through 6 months

    Process measure assessing video viewing behavior tracked through unique de-identified research numbers.

  3. Avatar preferences

    Time frame: Baseline through 6 months

    Frequency distribution of avatar speaker selections among Veterans who accessed the website

Study contacts

Contact information is provided by the study sponsor or research team.

Nicholas Vesom, MPH, CCRP

CONTACT

[email protected]

(650) 493-5000

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Collaborators

  • Palo Alto Veterans Institute for Research
  • VA Palo Alto Health Care System

Registry information

Official study title

EVERYVET (Empowering VEterans in Research effectivelY Using Virtual Engagement Tools): A Patient-Centered Study

Acronym: EVERYVET

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Aug 3, 2026
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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