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NCT Number: NCT07608120

Electrolyte Beverage Combined With Polyethylene Glycol for Colonoscopy Bowel Preparation

This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.

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Key information

Conditions

Colonoscopy Bowel Preparation Solutions Colorectal Cancer Screening

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, China

Location status: Recruiting

Location contact

Aimin Li

CONTACT

[email protected]

+86 13580317630

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-75 years scheduled to undergo elective colonoscopy
  • Meet the standard clinical indications for colonoscopy;
  • Able to understand and comply with the bowel preparation procedure and complete oral polyethylene glycol (PEG) intake as required;
  • Able to comply with study-related data collection and follow-up;
  • Provide written informed consent voluntarily.

Exclusion criteria

  • Previously diagnosed colorectal cancer, intestinal obstruction, or suspected intestinal obstruction;
  • Active gastrointestinal bleeding or a definite history of gastrointestinal bleeding within the past 4 weeks (including melena, hematochezia, or hematemesis);
  • Severe renal insufficiency, decompensated heart failure, significant electrolyte imbalance, or other conditions unsuitable for PEG bowel preparation;
  • Known allergy to polyethylene glycol or components of the electrolyte beverage used in the study;
  • Pregnant or breastfeeding women;
  • Any other condition considered by the investigators to make the participant unsuitable for the study.

Treatment and study plan

PEG With Water

Other

Polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy.

PEG With Low-dose Electrolyte Beverage

Other

Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy.

PEG With Medium-dose Electrolyte Beverage

Other

Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy.

Primary outcomes

  1. Adequate Bowel Preparation Rate

    Time frame: At the time of colonoscopy on Day 1

    Adequate bowel preparation is defined as a total Boston Bowel Preparation Scale (BBPS) score ≥6 with each colonic segment score ≥2 during colonoscopy.

Secondary outcomes

  1. Total Boston Bowel Preparation Scale Score

    Time frame: At the time of colonoscopy on Day 1

    Total Boston Bowel Preparation Scale (BBPS) score assessed during colonoscopy.

  2. Bowel Preparation Completion Rate

    Time frame: During bowel preparation within 1 hour before colonoscopy on Day 1

    Proportion of participants who complete the planned polyethylene glycol bowel preparation within 60 minutes.

  3. Adverse Event Rate

    Time frame: During bowel preparation within 1 hour before colonoscopy on Day 1

    Incidence of adverse events during bowel preparation, including nausea, vomiting, abdominal distension, abdominal pain, dizziness, and fatigue.

Study contacts

Contact information is provided by the study sponsor or research team.

Aimin Li

CONTACT

[email protected]

+86 13580317630

Sponsors and collaborators

Lead sponsor

Nanfang Hospital, Southern Medical University

Other

Registry information

Official study title

Randomized Controlled Trial of Different Ratios of Electrolyte Beverage and Water Combined With Polyethylene Glycol on Bowel Preparation Quality and Ingestion Rhythm Before Colonoscopy

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
May 27, 2026
Registry last updated
May 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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