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Completed

NCT Number: NCT05309161

Efficacy Testing of Crassocephalum Rabens Extract Capsules

This study is to investigate the improveing effects of the Crassocephalum rebens extract on skin conditions in normal people.

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Key information

Conditions

Aging

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chia Nan University of Pharmacy ＆ Science

Tainan, 71710, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age over 20 years
  • Healthy people

Exclusion criteria

  • Non-volunteer
  • Pregnant and lactating women
  • Hypersensitivity to the assigned product
  • Diagnosed with skin diseases, liver diseases, kinedy disease, and other severe diseases
  • Cosmetic, drug, or food allergies
  • Concurrent aesthetic treatments (e.g., intense pulse light, medical peelings, or laser therapy)
  • Aceepted aesthetic treatments one month ago before the study
  • Chronic sun exposure (over 3 hours/day)
  • The members of the research team

Treatment and study plan

Crassocephalum rabens extract

Dietary Supplement

dosage: a capsule (180 mg)/day; duration: 1 month

Primary outcomes

  1. Measurement of skin hydration

    Time frame: Week 0

    Corneometer CM825 is used to measure the moisture of upper cheek (unit: Corneometer® unit)

  2. Measurement of skin hydration

    Time frame: Week 4

    Corneometer CM825 is used to measure the moisture of upper cheek (unit: Corneometer® unit)

  3. Measurement of skin brightness

    Time frame: Week 0

    Chroma Meter MM500 is employed to measure the brightness of upper cheek (unit: L* value (L* range: 0-100)).

  4. Measurement of skin brightness

    Time frame: Week 4

    Chroma Meter MM500 is employed to measure the brightness of upper cheek (unit: L* value (L* range: 0-100)).

  5. Measurement of skin texture

    Time frame: Week 0

    Visia® skin analysis system is used to measure the skin texture of full face (unit: number of fine lines)

  6. Measurement of skin texture

    Time frame: Week 4

    Visia® skin analysis system is used to measure the skin texture of full face (unit: number of fine lines)

  7. Measurement of skin spots

    Time frame: Week 0

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of spots)

  8. Measurement of skin spots

    Time frame: Week 4

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of spots)

  9. Measurement of collagen content

    Time frame: Week 0

    DermaLab® Series SkinLab Combo (Cortex) is employed to measure skin collagen content of upper cheek (unit: collagen density)

  10. Measurement of collagen content

    Time frame: Week 4

    DermaLab® Series SkinLab Combo (Cortex) is employed to measure skin collagen content of upper cheek (unit: collagen density)

  11. Measurement of Crow's feet

    Time frame: Week 0

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of Visia® skin analysis system is used to measure the skin spots of full face (unit: number of fine lines around eyes)

  12. Measurement of Crow's feet

    Time frame: Week 4

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of Visia® skin analysis system is used to measure the skin spots of full face (unit: number of fine lines around eyes)

  13. Measurement of skin elasticity

    Time frame: Week 0

    Cutometer® is used to measure the skin elasticity of upper cheek (unit: mm)

  14. Measurement of skin elasticity

    Time frame: Week 4

    Cutometer® is used to measure the skin elasticity of upper cheek (unit: mm)

  15. Measurement of skin wrinkles

    Time frame: Week 0

    Visia® skin analysis system is used to measure the skin wrinkles of full face (unit: number of wrinkles)

  16. Measurement of skin wrinkles

    Time frame: Weeks 4

    Visia® skin analysis system is used to measure the skin wrinkles of full face (unit: number of wrinkles)

  17. Measurement of skin pores

    Time frame: Week 0

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of pores)

  18. Measurement of skin pores

    Time frame: Week 4

    Visia® skin analysis system is used to measure the skin spots of full face (unit: number of pores)

Sponsors and collaborators

Lead sponsor

Greenyn Biotechnology Co., Ltd.

Industry

Collaborators

  • Chia Nan University of Pharmacy ＆ Science

Registry information

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Apr 4, 2022
Registry last updated
Aug 3, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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